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dc.contributor.authorNicole Ngo-Giang-Huongen_US
dc.contributor.authorGonzague Jourdainen_US
dc.contributor.authorWasna Sirirungsien_US
dc.contributor.authorLuc Deckeren_US
dc.contributor.authorWoottichai Khamduangen_US
dc.contributor.authorSophie Le Cœuren_US
dc.contributor.authorSurat Sirinontakanen_US
dc.contributor.authorRosalin Somsamaien_US
dc.contributor.authorKarin Pagdien_US
dc.contributor.authorJittapol Hemvuttiphanen_US
dc.contributor.authorKenneth McIntoshen_US
dc.contributor.authorFrancis Barinen_US
dc.contributor.authorMarc Lallemanten_US
dc.description.abstractObjectives: The objectives of this study were to assess the prevalence and factors associated with hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected and -uninfected Thai pregnant women and the rate of HCV transmission to their infants. Patients and methods: Study subjects included 1435 HIV-infected pregnant women and their infants, enrolled in a perinatal HIV prevention trial, and a control group of 448 HIV-uninfected pregnant women. Women were screened for HCV antibodies with an enzyme immunoassay. Positive results were confirmed by recombinant immunoblot and HCV RNA quantification. Infants were tested for HCV antibodies at 18 months or for HCV RNA at between 6 weeks and 6 months. Results: Of the HIV-infected women, 2.9% were HCV-infected compared to 0.5% of HIV-uninfected women (p = 0.001). Only history of intravenous drug use was associated with HCV infection in HIV-infected women. Ten percent of infants born to co-infected mothers acquired HCV. The risk of transmission was associated with a high maternal HCV RNA (p = 0.012), but not with HIV-1 load or CD4 count. Conclusions: Acquisition of HCV through intravenous drug use partially explains the higher rate of HCV infection in HIV-infected Thai women than in HIV-uninfected controls. Perinatal transmission occurred in 10% of infants of HIV-HCV-co-infected mothers and was associated with high maternal HCV RNA. © 2009 International Society for Infectious Diseases.en_US
dc.titleHuman immunodeficiency virus-hepatitis C virus co-infection in pregnant women and perinatal transmission to infants in Thailanden_US
article.title.sourcetitleInternational Journal of Infectious Diseasesen_US
article.volume14en_US of research for development, Thailanden_US School of Public Healthen_US Mai Universityen_US Paris Descartesen_US Promotion Hospital Regional Center ien_US Hospitalen_US Hospitalen_US's Hospital Bostonen_US Francois-Rabelais Toursen_US
Appears in Collections:CMUL: Journal Articles

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