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dc.contributor.authorJialun Zhouen_US
dc.contributor.authorThira Sirisanthanaen_US
dc.contributor.authorSasisopin Kiertiburanakulen_US
dc.contributor.authorYi Ming A. Chenen_US
dc.contributor.authorNing Hanen_US
dc.contributor.authorPoh Lian Limen_US
dc.contributor.authorNagalingeswaran Kumarasamyen_US
dc.contributor.authorJun Y. Choien_US
dc.contributor.authorTuti P. Meratien_US
dc.contributor.authorEvy Yunihastutien_US
dc.contributor.authorShinichi Okaen_US
dc.contributor.authorAdeeba Kamarulzamanen_US
dc.contributor.authorPraphan Phanuphaken_US
dc.contributor.authorChristopher K.C. Leeen_US
dc.contributor.authorPatrick C.K. Lien_US
dc.contributor.authorSanjay Pujarien_US
dc.contributor.authorVanthanak Saphonnen_US
dc.contributor.authorMatthew G. Lawen_US
dc.description.abstractBackground: The aim of this study was to examine the relationship between trends in CD4 counts (slope) and HIV viral load (VL) after initiation of combination antiretroviral treatment (cART) in Asian patients in The TREAT Asia HIV Observational Database (TAHOD).Methods: Treatment-naive HIV-infected patients who started cART with three or more and had three or more CD4 count and HIV VL tests were included. CD4 count slopes were expressed as changes of cells per microliter per year. Predictors of CD4 count slopes from 6 months after initiation were assessed by random-effects linear regression models.Results: A total of 1676 patients (74% male) were included. The median time on cART was 4.2 years (IQR 2.5-5.8 years). In the final model, CD4 count slope was associated with age, concurrent HIV VL and CD4 count, disease stage, hepatitis B or C co-infection, and time since cART initiation. CD4 count continues to increase with HIV VL up to 20 000 copies/mL during 6-12 months after cART initiation. However, the HIV VL has to be controlled below 5 000, 4 000 and 500 copies/mL for the CD4 count slope to remain above 20 cells/microliter per year during 12-18, 18-24, and beyond 24 months after cART initiation.Conclusions: After cART initiation, CD4 counts continued to increase even when the concurrent HIV VL was detectable. However, HIV VL needed to be controlled at a lower level to maintain a positive CD4 count slope when cART continues. The effect on long-term outcomes through the possible development of HIV drug resistance remains uncertain. © 2010 Zhou et al; licensee BioMed Central Ltd.en_US
dc.titleTrends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: Results from The TREAT Asia HIV Observational Databaseen_US
article.title.sourcetitleBMC Infectious Diseasesen_US
article.volume10en_US Instituteen_US Mai Universityen_US Universityen_US Yang-Ming University Taiwanen_US Ditan Hospitalen_US Tock Seng Hospitalen_US Gaitonde Centre for AIDS Research and Educationen_US University College of Medicineen_US Udayanaen_US of Indonesia, RSUPN Dr. Cipto Mangunkusumoen_US Center for Global Health and Medicineen_US of Malaya Medical Centreen_US HIV Netherlands Australia Thailand Research Collaborationen_US Sungai Bulohen_US Elizabeth Hospital Hong Kongen_US of Infectious Diseasesen_US Center for HIV/AIDSen_US
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