Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJiraprapa Wipasaen_US
dc.contributor.authorChaisuree Suphavilaien_US
dc.contributor.authorLucy C. Okellen_US
dc.contributor.authorJackie Cooken_US
dc.contributor.authorPatrick H. Corranen_US
dc.contributor.authorKanitta Thaiklaen_US
dc.contributor.authorWitaya Liewsareeen_US
dc.contributor.authorEleanor M. Rileyen_US
dc.contributor.authorJulius Clemence R Hafallaen_US
dc.description.abstractAntibodies constitute a critical component of the naturally acquired immunity that develops following frequent exposure to malaria. However, specific antibody titres have been reported to decline rapidly in the absence of reinfection, supporting the widely perceived notion that malaria infections fail to induce durable immunological memory responses. Currently, direct evidence for the presence or absence of immune memory to malaria is limited. In this study, we analysed the longevity of both antibody and B cell memory responses to malaria antigens among individuals who were living in an area of extremely low malaria transmission in northern Thailand, and who were known either to be malaria naïve or to have had a documented clinical attack of P. falciparum and/or P. vivax in the past 6 years. We found that exposure to malaria results in the generation of relatively avid antigen-specific antibodies and the establishment of populations of antigen-specific memory B cells in a significant proportion of malaria-exposed individuals. Both antibody and memory B cell responses to malaria antigens were stably maintained over time in the absence of reinfection. In a number of cases where antigenspecific antibodies were not detected in plasma, stable frequencies of antigen-specific memory B cells were nonetheless observed, suggesting that circulating memory B cells may be maintained independently of long-lived plasma cells. We conclude that infrequent malaria infections are capable of inducing long-lived antibody and memory B cell responses. © 2010 Wipasa et al.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleLong-lived antibody and B cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivaxen_US
article.title.sourcetitlePLoS Pathogensen_US
article.volume6en_US Mai Universityen_US School of Hygiene & Tropical Medicineen_US of Disease Prevention and Controlen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.