Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/50188
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMyron S. Cohenen_US
dc.contributor.authorYing Q. Chenen_US
dc.contributor.authorMarybeth McCauleyen_US
dc.contributor.authorTheresa Gambleen_US
dc.contributor.authorMina C. Hosseinipouren_US
dc.contributor.authorNagalingeswaran Kumarasamyen_US
dc.contributor.authorJames G. Hakimen_US
dc.contributor.authorJohnstone Kumwendaen_US
dc.contributor.authorBeatriz Grinsztejnen_US
dc.contributor.authorJose H.S. Pilottoen_US
dc.contributor.authorSheela V. Godboleen_US
dc.contributor.authorSanjay Mehendaleen_US
dc.contributor.authorSuwat Chariyalertsaken_US
dc.contributor.authorBreno R. Santosen_US
dc.contributor.authorKenneth H. Mayeren_US
dc.contributor.authorIrving F. Hoffmanen_US
dc.contributor.authorSusan H. Eshlemanen_US
dc.contributor.authorEstelle Piwowar-Manningen_US
dc.contributor.authorLei Wangen_US
dc.contributor.authorJoseph Makhemaen_US
dc.contributor.authorLisa A. Millsen_US
dc.contributor.authorGuy De Bruynen_US
dc.contributor.authorIan Sanneen_US
dc.contributor.authorJoseph Eronen_US
dc.contributor.authorJoel Gallanten_US
dc.contributor.authorDiane Havliren_US
dc.contributor.authorSusan Swindellsen_US
dc.contributor.authorHeather Ribaudoen_US
dc.contributor.authorVanessa Elharraren_US
dc.contributor.authorDavid Burnsen_US
dc.contributor.authorTaha E. Tahaen_US
dc.contributor.authorKarin Nielsen-Sainesen_US
dc.contributor.authorDavid Celentanoen_US
dc.contributor.authorMax Essexen_US
dc.contributor.authorThomas R. Flemingen_US
dc.date.accessioned2018-09-04T04:26:12Z-
dc.date.available2018-09-04T04:26:12Z-
dc.date.issued2011-08-11en_US
dc.identifier.issn15334406en_US
dc.identifier.issn00284793en_US
dc.identifier.other2-s2.0-80051633217en_US
dc.identifier.other10.1056/NEJMoa1105243en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80051633217&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/50188-
dc.description.abstractBACKGROUND: Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. METHODS: In nine countries, we enrolled 1763 couples in which one partner was HIV-1-positive and the other was HIV-1-negative; 54% of the subjects were from Africa, and 50% of infected partners were men. HIV-1-infected subjects with CD4 counts between 350 and 550 cells per cubic millimeter were randomly assigned in a 1:1 ratio to receive antiretroviral therapy either immediately (early therapy) or after a decline in the CD4 count or the onset of HIV-1-related symptoms (delayed therapy). The primary prevention end point was linked HIV-1 transmission in HIV-1-negative partners. The primary clinical end point was the earliest occurrence of pulmonary tuberculosis, severe bacterial infection, a World Health Organization stage 4 event, or death. RESULTS: As of February 21, 2011, a total of 39 HIV-1 transmissions were observed (incidence rate, 1.2 per 100 person-years; 95% confidence interval [CI], 0.9 to 1.7); of these, 28 were virologically linked to the infected partner (incidence rate, 0.9 per 100 person-years, 95% CI, 0.6 to 1.3). Of the 28 linked transmissions, only 1 occurred in the earlytherapy group (hazard ratio, 0.04; 95% CI, 0.01 to 0.27; P<0.001). Subjects receiving early therapy had fewer treatment end points (hazard ratio, 0.59; 95% CI, 0.40 to 0.88; P = 0.01). CONCLUSIONS: The early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy. (Funded by the National Institute of Allergy and Infectious Diseases and others; HPTN 052 ClinicalTrials.gov number, NCT00074581.) Copyright © 2011 Massachusetts Medical Society.en_US
dc.subjectMedicineen_US
dc.titlePrevention of HIV-1 infection with early antiretroviral therapyen_US
dc.typeJournalen_US
article.title.sourcetitleNew England Journal of Medicineen_US
article.volume365en_US
article.stream.affiliationsUniversity of North Carolina School of Medicineen_US
article.stream.affiliationsFred Hutchinson Cancer Research Centeren_US
article.stream.affiliationsUniversity of Washington, Seattleen_US
article.stream.affiliationsFamily Health Internationalen_US
article.stream.affiliationsUniversity of North Carolina Project Malawien_US
article.stream.affiliationsCollege of Medicine-Johns Hopkins Projecten_US
article.stream.affiliationsY R Gaitonade Center for AIDS Research and Educationen_US
article.stream.affiliationsNational AIDS Research Institute Indiaen_US
article.stream.affiliationsUniversity of Zimbabween_US
article.stream.affiliationsFundacao Oswaldo Cruzen_US
article.stream.affiliationsHospital Geral de Rio de Janeiroen_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsHospital Nossa Senhora da Conceicaoen_US
article.stream.affiliationsFenway Healthen_US
article.stream.affiliationsHarvard School of Public Healthen_US
article.stream.affiliationsJohns Hopkins Universityen_US
article.stream.affiliationsJohns Hopkins Bloomberg School of Public Healthen_US
article.stream.affiliationsBotswana Harvard AIDS Institute Partnershipen_US
article.stream.affiliationsKenya Medical Research Instituteen_US
article.stream.affiliationsUniversity of Witwatersranden_US
article.stream.affiliationsUniversity of California, San Franciscoen_US
article.stream.affiliationsUniversity of Nebraska Medical Centeren_US
article.stream.affiliationsNational Institute of Allergy and Infectious Diseasesen_US
article.stream.affiliationsDavid Geffen School of Medicine at UCLAen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.