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dc.contributor.authorKessara Pathanapitoonen_US
dc.contributor.authorAnjo Riemensen_US
dc.contributor.authorNatedao Kongyaien_US
dc.contributor.authorWasna Sirirungsien_US
dc.contributor.authorPranee Leechanachaien_US
dc.contributor.authorSomsanguan Ausayakhunen_US
dc.contributor.authorViera Kalinina Ayusoen_US
dc.contributor.authorParadee Kunavisaruten_US
dc.contributor.authorJolanda Df De Groot-Mijnesen_US
dc.contributor.authorAniki Rothovaen_US
dc.description.abstractObjective: The objective of this study was to analyze human immunodeficiency virus (HIV) dynamics across the blood-retinal barrier and to determine whether the high levels of HIV in the eye are associated with any ocular disorders in HIV-infected patients. Design: This study included a prospective case series of 40 HIV-positive patients with uveitis. INTERVENTION:: Clinical and laboratory examinations included plasma and intraocular HIV-1 RNA loads as well as the clinical manifestations of uveitis. Results: Intraocular HIV-1 RNA was detected in 32% (13/40) of HIV-positive patients with uveitis. Intraocular HIV-1 RNA loads were associated with high HIV-1 RNA plasma loads (P < 0.001) and not being on HAART therapy (P = 0.005). In addition, detectable intraocular HIV-1 RNA levels were higher in patients with the absence of retinal lesions (P = 0.008). In three patients, the HIV load in the eye largely exceeded that of plasma. These three patients had all bilateral anterior uveitis and/or vitritis without retinal lesions and exhibited no evidence of other intraocular infectious agents causing uveitis than HIV itself. Conclusion: The eye can form a sanctuary where HIV might replicate and cause an inflammatory reaction. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleIntraocular and plasma HIV-1 RNA loads and HIV uveitisen_US
article.volume25en_US Mai Universityen_US Medical Center Utrechten_US
Appears in Collections:CMUL: Journal Articles

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