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dc.contributor.authorYoshiyuki Tohnoen_US
dc.contributor.authorSetsuko Tohnoen_US
dc.contributor.authorHiroyasu Satohen_US
dc.contributor.authorMotoharu Hayashien_US
dc.contributor.authorTakao Oishien_US
dc.contributor.authorTakeshi Minamien_US
dc.contributor.authorPasuk Mahakkanukrauhen_US
dc.description.abstractTo examine whether there were gender differences in the sino-atrial node (SAN), the authors investigated the gender difference in the SAN using monkey hearts by direct chemical analysis from a viewpoint of element contents. The used rhesus and Japanese monkeys consisted of 30 males (average age=6.5±7.5 years) and 30 females (average age=12.2±10.3 years), ranging in age from newborn to 30 years. The SAN tissues were removed from the anatomical position of monkey hearts and were confirmed by means of histological observation. After ashing with nitric acid and with perchloric acid, element contents of the SANs, such as Ca, P, S, Mg, Zn, Fe, and Na, were determined by inductively coupled plasma-atomic emission spectrometry. In addition, gender differences in the right atrial walls, left ventricular walls, mitral valves, and left coronary arteries of monkeys were also investigated as controls. It was found that the P content was significantly higher in females than in males in the SANs of monkeys, but the other six element contents, Ca, S, Mg, Zn, Fe, and Na, were not significantly different between males and females in the SANs of monkeys. Regarding the P content, a similar finding was also obtained in both the right atrial walls and the left ventricular walls of monkeys, but it was not obtained in the mitral valves and the left coronary arteries of monkeys. The P content of tissue is mostly determined by the nucleic acid (DNA and RNA) content and the phospholipid content of tissue. Nucleic acids in the cell nucleus and the cytosol, and phospholipids in the cell membrane are all indicators of metabolically active cells. It is reasonable to presume that the P content in the SAN indicates the active cell density, namely, the number of active cells per volume. Therefore, there is a possibility that the active cell density of the SAN is significantly higher in females than in males. © 2010 Springer Science+Business Media, LLC.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleGender differences in the phosphorus content of the sino-atrial nodes and other cardiac regions of monkeysen_US
article.title.sourcetitleBiological Trace Element Researchen_US
article.volume143en_US Mai Universityen_US Medical Universityen_US Universityen_US Universityen_US
Appears in Collections:CMUL: Journal Articles

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