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dc.contributor.authorJ. Sugarmanen_US
dc.contributor.authorA. Cornelien_US
dc.contributor.authorD. Donnellen_US
dc.contributor.authorT. Y. Liuen_US
dc.contributor.authorS. Roseen_US
dc.contributor.authorD. Celentanoen_US
dc.contributor.authorB. Jacksonen_US
dc.contributor.authorA. Aramrattanaen_US
dc.contributor.authorL. Weien_US
dc.contributor.authorY. Shaoen_US
dc.contributor.authorF. Lipingen_US
dc.contributor.authorR. Baolingen_US
dc.contributor.authorB. Dye Metzgeren_US
dc.description.abstractIntroduction: While quizzing during informed consent for research to ensure understanding has become commonplace, it is unclear whether the quizzing itself is problematic for potential participants. In this study, we address this issue in a multinational HIV prevention research trial enrolling injection drug users in China and Thailand. Methods: Enrolment procedures included an informed consent comprehension quiz. An informed consent survey followed. Results: 525 participants completed the informed consent survey (Heng County, China=255, Xinjiang, China=229, Chiang Mai, Thailand=41). Mean age was 33 and mean educational level was 8 yrs. While quizzing was felt to be a good way to determine if a person understands the nature of clinical trial participation (97%) and participants did not generally find the quiz to be problematic, minorities of respondents felt pressured (6%); anxious (5%); bored (5%); minded (5%); and did not find the questions easy (13%). In multivariate analysis, lower educational level was associated with not minding the quizzing (6e10 yrs vs 0e5 yrs: OR=0.27, p=0.03; more than 11 yrs vs 0e5 yrs: OR=0.18, p=0.03). There were also site differences (Heng County vs Xinjiang) in feeling anxious (OR=0.07; p=<0.01), not minding (OR=0.26; p=0.03), being bored (OR=0.25; p=0.01) and not finding the questions easy (OR=0.10; p=<0.01). Conclusions: Quizzing during the informed consent process can be problematic for a minority of participants. These problems may be associated with the setting in which research takes place and educational level. Further research is needed to develop, test and implement alternative methods of ensuring comprehension of informed consent.en_US
dc.subjectArts and Humanitiesen_US
dc.subjectSocial Sciencesen_US
dc.titleAre there adverse consequences of quizzing during informed consent for HIV research?en_US
article.title.sourcetitleJournal of Medical Ethicsen_US
article.volume37en_US Hopkins Universityen_US Johns Hopkins School of Medicineen_US Research Triangle Parken_US Hutchison Cancer Research Centeren_US Hopkins Bloomberg School of Public Healthen_US Mai Universityen_US for Disease Control and Preventionen_US Center for AIDS/STD Control and Preventionen_US of Pennsylvaniaen_US
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