พารามิเตอร์ที่เหมาะสมต่อการขึ้นรูปแผ่นเพลทยึดติดกระดูกจากวัสดุประสมของไฮดรอกซีอะปาไทต์และแก้วชีวภาพ

Abstract

Biomaterials have been recently developed and implemented in medical application as an alternative for reactivate or replace fractured parts of bones. Bioactive materials, such as Hydroxyapatite (HA) and bioactive glass (BG) have been increasingly implemented in bone substitution due to their biocompatibility and closely resemble the mineralized phase of human bone structures. Furthermore, the mentioned materials can be synthesized from natural resources (bovine bone and mollusk shell) with calcium-based structures. In this study, the synthesized materials were applied to bone fixation for damaged bone treatment. In addition, the formed composites were compressed by hydraulic pressing machine. The experimental design based on Response Surface Method (RSM) was implemented to evaluate the significant factors of forming condition consists of mixing ratio, pressure and holding time for pressing. The resulting scaffolds were evaluated for ultimate compressive strength and bending strength as the response. The results revealed that all forming conditions and some interaction term have a significant effect on the mechanical property of the composite scaffolds. Consequently, the average compressive strength (154.29 MPa), the average bending strength (17.15 MPa) and density (1.82 g/cm3) was obtained from the scaffold with a 4.53 wt% of BG, 23.41 MPa of pressure and 52.39 second of holding time. Consequently, the information from the mechanical tests was imported into Finite Element Analysis (FEA) in order to evaluate the impacted force behavior of the bone plate when subject to 200 Newton impacted load in axial direction. The result shows that the von Mises stress is 16.2 MPa and the critical location is at the bottom edge of the bone plate.