Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/45992
Title: Anti-Acinetobacter baumannii Activity of Volatile Oil Extracted from Medicinal Plants
Other Titles: ฤทธิ์ต้านเชื้อ Acinetobacter baumannii ของน้ำมันหอมระเหยสกัดจากพืชสมุนไพร
Authors: อมรรัตน์ อินทรสูต
ศิริวุฒิ สุขขี
ประสิทธิ์ ธาราวิจิตรกุล
Piyaorn Chornchoem
ปิยอร จอนเจิม
Keywords: oil extracted
Anti-Acinetobacter
Issue Date: Aug-2014
Publisher: เชียงใหม่ : บัณฑิตวิทยาลัย มหาวิทยาลัยเชียงใหม่
Abstract: Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. The improper use of antibiotics has result in emergence of multidrug resistant A. baumannii (MDR-A. baumannii). Therefore, the choice of available antibiotics is limited. The aim of the present study was to determine the antibacterial activity of volatile oils extracted from medicinal plants on the growth of MDR-A. baumannii. Volatile oils were extracted from 10 medicinal plants, including galangal, ginger, plai, lime, kaffir lime, sweet basil, tree basil, lemongrass, clove and cinnamon by water distillation method. All volatile oils were determined for their antibacterial activity against 30 strains of MDR-A. baumannii by agar disk diffusion and tea tree oil was used as positive control. The preliminary results demonstrated that 10 volatile oils possessed antibacterial activity against MDR-A. baumannii. Inhibition zones of cinnamon oil and clove oil were significantly larger than tea tree oil against MDR-A. baumannii (p<0.01). Moreover, inhibition zones of tree basil oil and tea tree oil showed no significant difference. Antibacterial activity assay by broth microdilution methods showed that volatile oils from cinnamon, clove, tree basil and kaffir lime possessed strong antibacterial activity and exhibited the MIC90 values of 0.25, 0.5, 1 and 1 mg/mL respectively and MBC90 values of 0.5, 1, 2 and 4 mg/mL, respectively. These results demonstrated that cinnamon oil showed the strongest antibacterial activity and thier major ingredients included cinnamaldehyde (75.89%), trans-cinnamyl acetate (7.07%), hydrocinnamaldehyde (2.39%) and 1,8-cineole (2.17%) when analyzed by Gas Chromatography-Mass Spectrometry. These results suggest that volatile oils extracted from cinnamon, clove, tree basil and kaffir lime may be used as alternative natural compounds to prevent and inhibit MDR-A. baumannii infection.
URI: http://cmuir.cmu.ac.th/jspui/handle/6653943832/45992
Appears in Collections:MED: Theses

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APPENDIX.pdfAPPENDIX3.62 MBAdobe PDFView/Open    Request a copy
CHAPTER 1.pdfCHAPTER 1171.83 kBAdobe PDFView/Open    Request a copy
CHAPTER 2.pdfCHAPTER 2981.49 kBAdobe PDFView/Open    Request a copy
CHAPTER 3.pdfCHAPTER 3113.53 kBAdobe PDFView/Open    Request a copy
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CHAPTER 6.pdfCHAPTER 6304.9 kBAdobe PDFView/Open    Request a copy
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CONTENT.pdfCONTENT323.33 kBAdobe PDFView/Open    Request a copy
COVER.pdfCOVER544.57 kBAdobe PDFView/Open    Request a copy
REFERENCE.pdfREFERENCE278.85 kBAdobe PDFView/Open    Request a copy


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