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Title: Active Compounds from Curcuma Comosa Roxb. for Multidrug Resistance Reversal and Nucleophosmin Inhibitory Abilities in Drug Resistance Leukemic Cells
Other Titles: สารออกฤทธิ์จาก Curcuma comosa Roxb. ต่อความสามารถในการปรับเปลี่ยนการดื้อยาหลายขนานและการยับยั้งนิวคลีโอฟอสมินในเซลล์มะเร็งเม็ดเลือดขาวดื้อยา
Authors: Natsima Viriyaadhammaa
Authors: Songyot Anuchapreeda
Natsima Viriyaadhammaa
Issue Date: Oct-2023
Publisher: Chiang Mai : Graduate School, Chiang Mai University
Abstract: This study aimed to explore the potential of main compounds from Curcuma comosa Roxb. in leukemia treatment. The Diarylheptanoid 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene (compound 1 or DDHPH) was obtained after purification from ethyl acetate (F-EtOAc) fractional extract, while diarylheptanoid trans-1,7-diphenyl-5-hydroxy-1-heptene (compound 2 or DHH) was obtained after purification from hexane (F-Hex) fractional extract. Both compounds 1 and 2 exhibited strong cytotoxicity against various cancer cell lines, while remaining nontoxicity toward normal white blood cells. Additionally, compound 1 demonstrated notable antioxidant and anti-inflammatory properties. This study focused on proteins associated with cell proliferation and cell death. WT1 protein, a marker for leukemic cell proliferation, was significantly decreased after F-EtOAC and compound 1 treatments in a time- and dose-dependent manner. Moreover, compound 1 was found to induce NPM localization, resulting in the upregulation of p53 leading to cell cycle arrest and apoptosis. On the other hand, compound 2 demonstrated a drug modulator property, enhancing the efficacy of chemotherapeutic agents in drug-resistant cells. In conclusion, this study successfully purified the main active compounds from C. comosa Roxb., including compound 1 and compound 2. These two compounds could reduce cancer cell survival and safe for normal cells, indicating their potential as models for drug development.
Appears in Collections:AMS: Theses

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