Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves

Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/70205

Title:	Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves
Authors:	Songyot Anuchapreeda Riki Anzawa Natsima Viriyaadhammaa Waranya Neimkhum Wantida Chaiyana Siriporn Okonogi Toyonobu Usuki
Authors:	Songyot Anuchapreeda Riki Anzawa Natsima Viriyaadhammaa Waranya Neimkhum Wantida Chaiyana Siriporn Okonogi Toyonobu Usuki
Keywords:	Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date:	15-Jul-2020
Abstract:	Copyright © 2020 Elsevier Ltd. All rights reserved. The leaves of the kaffir lime (Citrus hystrix) are commonly used in cuisine and folk medicine. The aim of this study was to isolate a bioactive compound in kaffir lime leaves and characterize its biological activity. The compound was isolated from a hexane fractional extract and identified as agrostophillinol. This is the first report of agrostophillinol isolated from kaffir lime leaves. In terms of cytotoxicity, agrostophillinol exhibited IC50 values of 36.27 ± 7.30 and 53.44 ± 10.63 μg/mL against EoL-1 and HL60 cells, respectively. Agrostophillinol also exhibited potent anti-inflammatory activity, significantly inhibiting IL-6 secretion.
URI:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086355236&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/70205
ISSN:	14643405
Appears in Collections:	CMUL: Journal Articles

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