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Title: US Immigration Westernizes the Human Gut Microbiome
Authors: Pajau Vangay
Abigail J. Johnson
Tonya L. Ward
Gabriel A. Al-Ghalith
Robin R. Shields-Cutler
Benjamin M. Hillmann
Sarah K. Lucas
Lalit K. Beura
Emily A. Thompson
Lisa M. Till
Rodolfo Batres
Bwei Paw
Shannon L. Pergament
Pimpanitta Saenyakul
Mary Xiong
Austin D. Kim
Grant Kim
David Masopust
Eric C. Martens
Chaisiri Angkurawaranon
Rose McGready
Purna C. Kashyap
Kathleen A. Culhane-Pera
Dan Knights
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Nov-2018
Abstract: © 2018 Elsevier Inc. Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations. Migration from a non-western nation to the United States is found to be associated with a loss in gut microbiome diversity and function in a manner that may predispose individuals to metabolic disease.
ISSN: 10974172
Appears in Collections:CMUL: Journal Articles

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