Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial

Susan H. Eshleman; Sarah E. Hudelson; Andrew D. Redd; Ronald Swanstrom; San San Ou; Xinyi Cindy Zhang; Li Hua Ping; Estelle Piwowar-Manning; Stephen F. Porcella; Matthew F. Sievers; Craig A. Martens; Daniel Bruno; Elena Dukhovlinova; Marybeth McCauley; Theresa Gamble; Jessica M. Fogel; Devin Sabin; Thomas C. Quinn; Laurence Gunde; Madalitso Maliwichi; Nehemiah Nhando; Victor Akelo; Sikhulile Moyo; Ravindre Panchia; Nagalingeswaran Kumarasamy; Nuntisa Chotirosniramit; Marineide Gonçalves De Melo; Jose Pilotto; Beatriz Grinsztejn; Kenneth Mayer; Ying Q. Chen; James P. Hughes; Myron S. Cohen

Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/57842

Title:	Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial
Authors:	Susan H. Eshleman Sarah E. Hudelson Andrew D. Redd Ronald Swanstrom San San Ou Xinyi Cindy Zhang Li Hua Ping Estelle Piwowar-Manning Stephen F. Porcella Matthew F. Sievers Craig A. Martens Daniel Bruno Elena Dukhovlinova Marybeth McCauley Theresa Gamble Jessica M. Fogel Devin Sabin Thomas C. Quinn Laurence Gunde Madalitso Maliwichi Nehemiah Nhando Victor Akelo Sikhulile Moyo Ravindre Panchia Nagalingeswaran Kumarasamy Nuntisa Chotirosniramit Marineide Gonçalves De Melo Jose Pilotto Beatriz Grinsztejn Kenneth Mayer Ying Q. Chen James P. Hughes Myron S. Cohen
Authors:	Susan H. Eshleman Sarah E. Hudelson Andrew D. Redd Ronald Swanstrom San San Ou Xinyi Cindy Zhang Li Hua Ping Estelle Piwowar-Manning Stephen F. Porcella Matthew F. Sievers Craig A. Martens Daniel Bruno Elena Dukhovlinova Marybeth McCauley Theresa Gamble Jessica M. Fogel Devin Sabin Thomas C. Quinn Laurence Gunde Madalitso Maliwichi Nehemiah Nhando Victor Akelo Sikhulile Moyo Ravindre Panchia Nagalingeswaran Kumarasamy Nuntisa Chotirosniramit Marineide Gonçalves De Melo Jose Pilotto Beatriz Grinsztejn Kenneth Mayer Ying Q. Chen James P. Hughes Myron S. Cohen
Keywords:	Medicine
Issue Date:	1-Jan-2017
Abstract:	Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.
URI:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84983064904&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/57842
ISSN:	10779450 15254135
Appears in Collections:	CMUL: Journal Articles

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