Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/57714
Title: Human Papillomavirus infection and cervical lesions in HIV infected women on antiretroviral treatment in Thailand
Authors: Tristan Delory
Nicole Ngo-Giang-Huong
Samreung Rangdaeng
Nantasak Chotivanich
Aram Limtrakul
Chaiwat Putiyanun
Pornnapa Suriyachai
Wanmanee Matanasarawut
Tapnarong Jarupanich
Prateung Liampongsabuddhi
Isabelle Heard
Gonzague Jourdain
Marc Lallemant
Sophie Le Coeur
Kevin Zarca
Florence Brunet-Possenti
Alexandre Blake
Thomas Althaus
Céline Gallot
Alice Desbiolles
Florence Fayard
Fadia Dib
Diane Le Pluart
Myrtille Proute
Métrey Tiv
Sukit Banchongkit
Chureeratana Bowonwatanuwong
Sudanee Buranabanjasatean
Apichat Chutanunta
Naree Eiamsirikit
Keywords: Medicine
Issue Date: 1-May-2017
Abstract: © 2017 The British Infection Association Objectives To estimate the prevalence and factors associated with Human Papillomavirus (HPV) infection, HPV genotypes and cytological/histological high-grade (HSIL+/CIN2+) lesions. Methods We conducted a cross-sectional study within a prospective cohort of HIV-infected women on combination antiretroviral therapy (cART). Cervical specimens were collected for cytology and HPV genotyping (Papillocheck®). Any women with High-Risk-HPV (HR-HPV), and/or potentially HR-HPV (pHR-HPV) and/or ASC-US or higher (ASC-US+) lesions were referred for colposcopy. Factors associated with HR-HPV infection and with HSIL+/CIN2+ lesions were investigated using mixed-effects logistic regression models. Results 829 women were enrolled: median age 40.4 years, on cART for a median of 6.9 years, median CD4 cell-count 536 cells/mm3, and 788 (96%) with HIV-viral load<50copies/mL. Of 214 (26%) infected with HPV: 159 (19%) had ≥1 HR-HPV, of whom 38 (5%) HPV52, 22 (3%) HPV16, 9 (1%) HPV18; 21 (3%) had pHR-HPV, 34 (4%) low risk-HPV infection, and 56 (26%) had multiple genotypes. Younger age, low CD4 cell-counts and low education were independently associated with HR-HPV infection. 72 women (9%) had ASC-US+ and 28 (3%) HSIL+/CIN2+ lesions. HR-HPV infection was independently associated with HSIL+/CIN2+ lesions. Conclusion The prevalence of HPV infection and of cervical lesions was low. The HPV genotype distribution supports the use of 9-valent vaccine in Thailand.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015384329&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/57714
ISSN: 15322742
01634453
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.