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dc.contributor.authorTristan Deloryen_US
dc.contributor.authorNicole Ngo-Giang-Huongen_US
dc.contributor.authorSamreung Rangdaengen_US
dc.contributor.authorNantasak Chotivanichen_US
dc.contributor.authorAram Limtrakulen_US
dc.contributor.authorChaiwat Putiyanunen_US
dc.contributor.authorPornnapa Suriyachaien_US
dc.contributor.authorWanmanee Matanasarawuten_US
dc.contributor.authorTapnarong Jarupanichen_US
dc.contributor.authorPrateung Liampongsabuddhien_US
dc.contributor.authorIsabelle Hearden_US
dc.contributor.authorGonzague Jourdainen_US
dc.contributor.authorMarc Lallemanten_US
dc.contributor.authorSophie Le Coeuren_US
dc.contributor.authorKevin Zarcaen_US
dc.contributor.authorFlorence Brunet-Possentien_US
dc.contributor.authorAlexandre Blakeen_US
dc.contributor.authorThomas Althausen_US
dc.contributor.authorCéline Galloten_US
dc.contributor.authorAlice Desbiollesen_US
dc.contributor.authorFlorence Fayarden_US
dc.contributor.authorFadia Diben_US
dc.contributor.authorDiane Le Pluarten_US
dc.contributor.authorMyrtille Prouteen_US
dc.contributor.authorMétrey Tiven_US
dc.contributor.authorSukit Banchongkiten_US
dc.contributor.authorChureeratana Bowonwatanuwongen_US
dc.contributor.authorSudanee Buranabanjasateanen_US
dc.contributor.authorApichat Chutanuntaen_US
dc.contributor.authorNaree Eiamsirikiten_US
dc.description.abstract© 2017 The British Infection Association Objectives To estimate the prevalence and factors associated with Human Papillomavirus (HPV) infection, HPV genotypes and cytological/histological high-grade (HSIL+/CIN2+) lesions. Methods We conducted a cross-sectional study within a prospective cohort of HIV-infected women on combination antiretroviral therapy (cART). Cervical specimens were collected for cytology and HPV genotyping (Papillocheck®). Any women with High-Risk-HPV (HR-HPV), and/or potentially HR-HPV (pHR-HPV) and/or ASC-US or higher (ASC-US+) lesions were referred for colposcopy. Factors associated with HR-HPV infection and with HSIL+/CIN2+ lesions were investigated using mixed-effects logistic regression models. Results 829 women were enrolled: median age 40.4 years, on cART for a median of 6.9 years, median CD4 cell-count 536 cells/mm3, and 788 (96%) with HIV-viral load<50copies/mL. Of 214 (26%) infected with HPV: 159 (19%) had ≥1 HR-HPV, of whom 38 (5%) HPV52, 22 (3%) HPV16, 9 (1%) HPV18; 21 (3%) had pHR-HPV, 34 (4%) low risk-HPV infection, and 56 (26%) had multiple genotypes. Younger age, low CD4 cell-counts and low education were independently associated with HR-HPV infection. 72 women (9%) had ASC-US+ and 28 (3%) HSIL+/CIN2+ lesions. HR-HPV infection was independently associated with HSIL+/CIN2+ lesions. Conclusion The prevalence of HPV infection and of cervical lesions was low. The HPV genotype distribution supports the use of 9-valent vaccine in Thailand.en_US
dc.titleHuman Papillomavirus infection and cervical lesions in HIV infected women on antiretroviral treatment in Thailanden_US
article.title.sourcetitleJournal of Infectionen_US
article.volume74en_US de Recherche pour le Développement (IRD) UMI 174-PHPTen_US Mai Universityen_US Saint-Louisen_US Institut National d' Etudes Demographiquesen_US School of Public Healthen_US Regional Hospitalen_US Hospitalen_US Ministry of Public Healthen_US Hospitalen_US Hospitalen_US Hospitalen_US Pasteur, Parisen_US Pitie Salpetriereen_US
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