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Title: TCT-mediated synthesis of N-acylbenzotriazoles in aqueous media
Authors: Sirawit Wet-Osot
Wong Phakhodee
Mookda Pattarawarapan
Keywords: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 16-Dec-2015
Abstract: © 2015 Elsevier Ltd. All rights reserved. The synthesis of N-acylbenzotriazoles has been demonstrated by the 2,4,6-trichloro-1,3,5-triazine (TCT)-mediated condensation of carboxylic acids with 1H-benzotriazole in aqueous media. In saturated aqueous sodium bicarbonate, TCT was found to be relatively stable and functioned as an efficient acid activator in the acyl transfer process. This operationally simple and economic method allows the scalable synthesis of N-acylbenzotriazoles in good to excellent yields.
ISSN: 18733581
Appears in Collections:CMUL: Journal Articles

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