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|Title:||TCT-mediated synthesis of N-acylbenzotriazoles in aqueous media|
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics|
|Abstract:||© 2015 Elsevier Ltd. All rights reserved. The synthesis of N-acylbenzotriazoles has been demonstrated by the 2,4,6-trichloro-1,3,5-triazine (TCT)-mediated condensation of carboxylic acids with 1H-benzotriazole in aqueous media. In saturated aqueous sodium bicarbonate, TCT was found to be relatively stable and functioned as an efficient acid activator in the acyl transfer process. This operationally simple and economic method allows the scalable synthesis of N-acylbenzotriazoles in good to excellent yields.|
|Appears in Collections:||CMUL: Journal Articles|
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