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|Title:||A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media|
|Keywords:||Biochemistry, Genetics and Molecular Biology|
Pharmacology, Toxicology and Pharmaceutics
|Abstract:||© 2015 Elsevier Ltd. All rights reserved. A convenient one-pot, two-step procedure for the synthesis of ketone cyanohydrin esters in aqueous media is reported using N-acylbenzotriazoles as the acylating agents. In saturated aqueous sodium bicarbonate containing a catalytic amount of tetrabutylammonium bromide, the reaction of ketones with potassium cyanide and N-acylbenzotriazoles proceeded readily at room temperature to provide the corresponding O-acyl cyanohydrin derivatives in good to excellent yields.|
|Appears in Collections:||CMUL: Journal Articles|
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