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Title: A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media
Authors: Sirawit Wet-Osot
Mookda Pattarawarapan
Wong Phakhodee
Keywords: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 30-Dec-2015
Abstract: © 2015 Elsevier Ltd. All rights reserved. A convenient one-pot, two-step procedure for the synthesis of ketone cyanohydrin esters in aqueous media is reported using N-acylbenzotriazoles as the acylating agents. In saturated aqueous sodium bicarbonate containing a catalytic amount of tetrabutylammonium bromide, the reaction of ketones with potassium cyanide and N-acylbenzotriazoles proceeded readily at room temperature to provide the corresponding O-acyl cyanohydrin derivatives in good to excellent yields.
ISSN: 18733581
Appears in Collections:CMUL: Journal Articles

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