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Title: Labdane-type diterpenes from Hedychium gardnerianum with potent cytotoxicity against human small cell lung cancer cells
Authors: Iyared Kumrit
Apichart Suksamrarn
Puttinan Meepawpan
Sineenard Songsri
Nuchnipa Nuntawong
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jul-2010
Abstract: Seven labdane-type diterpenes, coronarin E, coronarin A, yunnancoronarin A, yunnancoronarin B, hedyforrestin B, villosin, and hedyforrestin C were isolated from the rhizome of Hedychium gardnerianum and evaluated for cytotoxic activity against human small cell lung cancer (NCI-H187) and non-cancerous Vero cells. The results showed that villosin exhibited potent cytotoxic activity with IC50 of 0.40 μM, which was higher than that of the drug ellipticine (IC50 1.79 μM). Moreover, ellipticine was very toxic to Vero cells (IC50 7.47 μM) whereas the toxicity of villosin was undetectable at concentration lower than 166.42 μM. The results have indicated that the lactone ring is essential for high cytotoxic activity and that the presence of a hydroxyl group at the 6 or 7 position causes decrease in activity. The very high cytotoxicity against the NCI-H187 cells and the exceptionally high selectivity index (>416) of villosin suggested that this compound may be used as a potential lead molecule for antitumor therapeutic development. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN: 10991573
Appears in Collections:CMUL: Journal Articles

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