Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorIyared Kumriten_US
dc.contributor.authorApichart Suksamrarnen_US
dc.contributor.authorPuttinan Meepawpanen_US
dc.contributor.authorSineenard Songsrien_US
dc.contributor.authorNuchnipa Nuntawongen_US
dc.description.abstractSeven labdane-type diterpenes, coronarin E, coronarin A, yunnancoronarin A, yunnancoronarin B, hedyforrestin B, villosin, and hedyforrestin C were isolated from the rhizome of Hedychium gardnerianum and evaluated for cytotoxic activity against human small cell lung cancer (NCI-H187) and non-cancerous Vero cells. The results showed that villosin exhibited potent cytotoxic activity with IC50 of 0.40 μM, which was higher than that of the drug ellipticine (IC50 1.79 μM). Moreover, ellipticine was very toxic to Vero cells (IC50 7.47 μM) whereas the toxicity of villosin was undetectable at concentration lower than 166.42 μM. The results have indicated that the lactone ring is essential for high cytotoxic activity and that the presence of a hydroxyl group at the 6 or 7 position causes decrease in activity. The very high cytotoxicity against the NCI-H187 cells and the exceptionally high selectivity index (>416) of villosin suggested that this compound may be used as a potential lead molecule for antitumor therapeutic development. Copyright © 2009 John Wiley & Sons, Ltd.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleLabdane-type diterpenes from Hedychium gardnerianum with potent cytotoxicity against human small cell lung cancer cellsen_US
article.title.sourcetitlePhytotherapy Researchen_US
article.volume24en_US Mai Universityen_US Universityen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.