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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50409| Title: | A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity |
| Authors: | Kanchana Pumsalid Haruthai Thaisuchat Chatchanok Loetchutinat Narong Nuntasaen Puttinan Meepowpan Wilart Pompimon |
| Authors: | Kanchana Pumsalid Haruthai Thaisuchat Chatchanok Loetchutinat Narong Nuntasaen Puttinan Meepowpan Wilart Pompimon |
| Keywords: | Agricultural and Biological Sciences;Medicine;Pharmacology, Toxicology and Pharmaceutics |
| Issue Date: | 1-Dec-2010 |
| Abstract: | Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50values in the range of 2.64-3.58 μg.mL-1for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL-1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751539201&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50409 |
| ISSN: | 15559475 1934578X |
| Appears in Collections: | CMUL: Journal Articles |
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