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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kanchana Pumsalid | en_US |
| dc.contributor.author | Haruthai Thaisuchat | en_US |
| dc.contributor.author | Chatchanok Loetchutinat | en_US |
| dc.contributor.author | Narong Nuntasaen | en_US |
| dc.contributor.author | Puttinan Meepowpan | en_US |
| dc.contributor.author | Wilart Pompimon | en_US |
| dc.date.accessioned | 2018-09-04T04:40:47Z | - |
| dc.date.available | 2018-09-04T04:40:47Z | - |
| dc.date.issued | 2010-12-01 | en_US |
| dc.identifier.issn | 15559475 | en_US |
| dc.identifier.issn | 1934578X | en_US |
| dc.identifier.other | 2-s2.0-78751539201 | en_US |
| dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751539201&origin=inward | en_US |
| dc.identifier.uri | http://cmuir.cmu.ac.th/jspui/handle/6653943832/50409 | - |
| dc.description.abstract | Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50values in the range of 2.64-3.58 μg.mL-1for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL-1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control. | en_US |
| dc.subject | Agricultural and Biological Sciences | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity | en_US |
| dc.type | Journal | en_US |
| article.title.sourcetitle | Natural Product Communications | en_US |
| article.volume | 5 | en_US |
| article.stream.affiliations | Rajabhat University | en_US |
| article.stream.affiliations | Chiang Mai University | en_US |
| article.stream.affiliations | The Forest Herbarium, Thailand Ministry of Natural Resources and Environment | en_US |
| Appears in Collections: | CMUL: Journal Articles | |
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