การศึกษาเศษอาหารในลำไส้เล็กส่วนต้นเพื่อเป็นวิธีเสริมในการตรวจทางพิษวิทยา

Abstract

The objective of this study was usingduodenal contentas an alternative or an enhance specimen in toxicology instead of gastric content. The samples werecollected from 30 corpseswhich died fromunknown cause with history of toxic substances or drug exposure. The samples were extracted with acids and bases and then analyzed byliquidchromatography - mass spectrometry (LC-MS-MS). The results werecompared duodenal content with gastric contentusingblood and urineas gold standards. Toxic substances or drugswere found in 25 cases (83.30%).The sensitivity, specificity and accuracy of the duodenal content versus the gastric content which were calculated and compared with blood were76.67:80.00, 41.67:25.00, 70.83:70.83andurine were68.29:73.17, 27.27:18.18 and 59.62: 61.54 respectively. Statistic analysis usingChi-square showedthat there was no significantdifference between duodenal and gastric content (p>0.05). Then, the duodenal content can be used as an alternative specimen for toxicologydiagnosis.