การหาสภาวะที่เหมาะสมสำหรับการขึ้นรูปแผ่นแปะนำส่งผ่านผิวหนังจากพีวีเอเป็นหลักโดยการหล่อเทป

Abstract

This research aims to study the relationship between the mixture ratios of polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), glycerol (GLY), and deionized water (DW) with the viscosity of the solution. This is achieved by using the Extreme Vertices Mixture Design and finding suitable conditions for forming transdermal patches using the tape casting method through Factorial designs and Central Composite designs. To explain the relationship of the mixtures with viscosity, out of a total of 17 formulations from the Extreme Vertices Mixture Design, the viscosity of the solution was measured at a temperature of 80-90°C. From the regression analysis, it was found that the Special quartic model was the most appropriate with a standard deviation value of 297 and an R-sq value of 99.80%. The main effects of the components PVA, PVP, GLY, and DW significantly influenced the viscosity. In assessing the physical characteristics of transdermal patches produced using the molding method, it was found that formulations 5 to 13 exhibited favorable physical properties. All nine formulations were prepared, underwent rheological testing of the solution, and were manufactured using the tape casting method to assess tensile strength. The results of the 2-sample t-test on the rheological properties revealed that an increased amount of PVA significantly resulted in an increase in Bingham yield stress and viscosity within the 95% confidence interval. Meanwhile, a decrease in the amount of PVP or an increase in the amount of GLY resulted in a significant increase in the viscosity. In the analysis of the main effects of ingredients on tensile strength, a clear trend emerges: an increase in PVA content leads to an increase in tensile strength, whereas increasing the amount of PVP or GLY results in a decrease in tensile strength. Additionally, increasing the amount of GLY leads to an increase in the percentage of elongation at break. Nevertheless, the statistical test results confirmed that only increasing the PVA content had a significant effect on increasing tensile strength, while altering the amount of PVA, PVP, or GLY did not significantly change the elongation. From the testing of 9 formulations, it was found that the mixture ratio of formula 10 (17.5/8.25/4.75) exhibited the highest tensile strength at 9.38 ± 1.78 MPa. Additionally, formulations 9, 10, and 11 were selected as factors for determining tape casting conditions, with casting speed (A) and formulation ratio (B). Considering the responsive factors include tensile strength, percentage elongation at break, peel force, and percentage of swelling. Response Optimization analysis results consider the properties of high tensile strength, low percentage of elongation at break, and low percentage of swelling. The response optimization study shows that factor A at level (1.129), equivalent to 2.12 cm/s, and factor B at level (-), Formula 24 (17.5/8.25/8.98/63.77/1.5), are the appropriate situations.