การประเมินความถูกต้องของปริมาณรังสีรายวันจากโปรแกรมพรีไซส์อาร์ทสำหรับการฉายรังสีมะเร็งหลังโพรงจมูกด้วยเครื่องฉายรังสีภาพนำแบบเกลียวหมุน

Abstract

PreciseART is an adaptive radiation therapy software included in the Precision treatment planning system (TPS) in Helical Tomotherapy. The feasibility of PreciseART as a trigger tool demonstrates to have benefits regarding the monitoring of the target and organ doses during the treatment course. This study aims to verify the accuracy of the PreciseART software for dose recalculation by comparing it with the TPS in both phantom and patient studies and its efficiency as a triggering tool. The kVCT imaging system (ClearRT) in Radixact X9 was used to acquire the daily image for dose recalculation. The dosimetric parameters for PTV70, spinal cord, and both parotid glands were analyzed to assess the accuracy of PreciseART software in terms of dose difference. In the phantom study, the dosimetric parameters of the Rando phantom were recalculated in TPS and compared with results from the PreciseART. In the patient study, 10 NPC patients were monitored for dose variation during the course of treatment. The dose criteria for tolerance and action level were determined. The treatment fractions which were alerted in PreciseART were verified and compared potentially facilitating recalculating on TPS. The phantom study showed no significant dosimetric difference between two dose calculation systems (p-value = 1.000), with a maximum dose variation within 1.5%. In the patient study, patients there were notable differences with the PreciseART system. However, there were no significant dosimetric difference in daily dose between PreciseART and TPS (p-value = 0.149), with a maximum variation of 2.3%. The triggered alerts indicated compliance with the setup of the dose criteria levels. The daily dose of PreciseART showed good agreement with the TPS calculation. The alerts effectively indicated compliance with dose criteria, supporting the clinical use of PreciseART for adaptive replanning alerts.