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Title: Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine
Authors: Pornprasert S.
Mary J.-Y.
Faye A.
Leechanachai P.
Limtrakul A.
Rugpao S.
Sirivatanapa P.
Gomuthbutra V.
Matanasaravoot W.
Le Coeur S.
Lallemant M.
Barre-Sinoussi F.
Menu E.
Ngo-Giang-Huong N.
Ayouba A.
Chailert S.
Chaouat G.
Derrien M.
Dolcini G.
Eteki N.
Kfutwah A.J.
Kouo O.
Lemen B.
Maldonado-Estrada J.
Nerrienet E.
Njinku B.
Scarlatti G.
Tejiokem M.
Tene G.
Issue Date: 2009
Abstract: Placental cytokine balance may be critical for the control of mother-to-child transmission (MTCT) of HIV. We assessed whether the type and duration of antiretrovirals used for prevention of HIV-1-MTCT modified the inflammatory cytokine profile. We investigated the levels of cytokine expression in the placentas of 61 HIV-1-infected women who received zidovudine (ZDV) plus single dose nevirapine (SD-NVP) or ZDV only for prevention of MTCT. Placentas of 38 HIV-1-uninfected women were included as controls. All placentas were obtained after vaginal delivery. Levels of mRNA and cytokine expression were quantified using real-time PCR and ELISA, respectively, in placental explants and 24-hour culture supernatants and analyzed in relation to the women's characteristics and the type and duration of antiretroviral prophylaxis. HIV-1-infected and uninfected women did not show any differences in the expression of placental cytokine secretion except for a trend toward lower TNF-10 mRNA levels in HIV-1-infected women. Within the HIV-1-infected group, women who were exposed to a long duration of ZDV (>72 days) or received SD-NVP less than 5h prior to delivery, more frequently expressed detectable levels of IL-10 in their placentas (32% versus 7% (p = 0.01) and 32% versus 5% (p = 0.02), respectively). No infant was found to be HIV-1-infected. Our results showed a normalization of the placental cytokine balance in HIV-1-infected women receiving antiretroviral prophylaxis. Furthermore, the type and duration of antiretroviral prophylaxis have an impact on the placental anti-inflammatory IL-10 expression level, which may contribute to controlling HIV replication at the placental level, thus reducing MTCT of HIV-1. © 2009 Bentham Science Publishers Ltd.
ISSN: 1570162X
Appears in Collections:AMS: Journal Articles

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