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Title: | Pharmacokinetics of darunavir and cobicistat in pregnant and postpartum women with HIV |
Authors: | Jeremiah D. Momper Jiajia Wang Alice Stek David E. Shapiro Gwendolyn B. Scott Mary E. Paul Irma L. Febo Sandra Burchett Elizabeth Smith Nahida Chakhtoura Kayla Denson Kittipong Rungruengthanakit Kathleen George Derek Z. Yang Edmund V. Capparelli Mark Mirochnick Brookie M. Best |
Authors: | Jeremiah D. Momper Jiajia Wang Alice Stek David E. Shapiro Gwendolyn B. Scott Mary E. Paul Irma L. Febo Sandra Burchett Elizabeth Smith Nahida Chakhtoura Kayla Denson Kittipong Rungruengthanakit Kathleen George Derek Z. Yang Edmund V. Capparelli Mark Mirochnick Brookie M. Best |
Keywords: | Immunology and Microbiology;Medicine |
Issue Date: | 1-Jul-2021 |
Abstract: | Objective: To evaluate darunavir and cobicistat pharmacokinetics during pregnancy compared with postpartum and in infant washout samples after delivery. Design: Nonrandomized, open-label, parallel-group, multicenter phase-IV prospective study of darunavir and cobicistat pharmacokinetics in pregnant women with HIV and their children in the United States. Methods: Intensive steady-state 24-h pharmacokinetic profiles were performed after administration of 800 mg of darunavir and 150 mg of cobicistat orally in fixed dose combination once-daily during the second trimester, third trimester, and postpartum. Infant washout samples were collected after birth. Darunavir and cobicistat were measured in plasma by validated HPLC-UV and liquid chromatography with tandem mass spectrometry detection (LC-MS)/MS assays, respectively. A two-tailed Wilcoxon signed-rank test (α = 0.10) was employed for paired within-participant comparisons. Results: A total of 29 pregnant women receiving darunavir and cobicistat once-daily enrolled in the study. Compared with paired postpartum data, darunavir AUC0 - 24was 53% lower in the second trimester [n = 12, P = 0.0024, geometric mean of ratio (GMR)=0.47, 90% confidence interval (CI) 0.33 - 0.68] and 56% lower in the third trimester (n = 18, P < 0.0001, GMR = 0.44, 90% CI 0.36 - 0.54), whereas cobicistat AUC0 - 24was 50% lower in the second trimester (n = 12, P = 0.0024, GMR = 0.50, 90% CI 0.36-0.69) and 56% lower in the third trimester (n = 18, P < 0.0001, GMR = 0.44, 90% CI 0.35-0.55). Placental transfer of darunavir and cobicistat was limited. Conclusion: Standard darunavir/cobicistat dosing during pregnancy results in significantly lower exposure during pregnancy, which may increase the risk of virologic failure and perinatal transmission. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85107443865&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/76721 |
ISSN: | 14735571 02699370 |
Appears in Collections: | CMUL: Journal Articles |
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