Preparation and some physical characterization of rice starch-carboxymethyl cellulose as hemostatic film

Abstract

Rice starch (RS) and carboxymethyl cellulose (CMC) are natural polymers that can be widely used for numerous biomedical applications such as hydrogels, capsules, drug delivery system, wound dressing. The purpose of this study was to prepare and investigate the appropriate weight ratio of RS/CMC blend films by solution casting technique. The swelling ratio and solubility were evaluated. The mechanical properties, intermolecular interaction, and morphology were also analyzed by the universal mechanical testing, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM), respectively. The results indicated that the suitable ratio of RS/CMC blend film was 60/40. The swelling ratio, solubility, tensile strength, and elongation at break were 46.8±0.3 times, 21.63±0.72 %, 30.4±1.5 MPa and 5.76±0.31 %, respectively. Moreover, the physical linkages exhibited mainly between the hydroxyl groups of RS and the carboxyl groups of CMC. In addition, the cross-sectional SEM images of blended films showed the miscibility of RS and CMC. This study suggested that the RS/CMC blended film can be used as a hemostatic film.