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Title: | A new anti-austerity agent, 4′-O-methylgrynullarin from Derris scandens induces PANC-1 human pancreatic cancer cell death under nutrition starvation via inhibition of Akt/mTOR pathway |
Authors: | Sijia Sun Dya Fita Dibwe Min Jo Kim Ashraf M. Omar Nguyen Duy Phan Haruka Fujino Nusrin Pongterdsak Kritsaya Chaithatwatthana Ampai Phrutivorapongkul Suresh Awale |
Authors: | Sijia Sun Dya Fita Dibwe Min Jo Kim Ashraf M. Omar Nguyen Duy Phan Haruka Fujino Nusrin Pongterdsak Kritsaya Chaithatwatthana Ampai Phrutivorapongkul Suresh Awale |
Keywords: | Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics |
Issue Date: | 15-May-2021 |
Abstract: | An ethanolic extract of Derris scandens flowers showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived condition, with a PC50 value of 0.7 μg/mL. Phytochemical investigation of this active extract led to the isolation of four prenylated isoflavones (1–4) including a new compound named 4′-O-methylgrynullarin (1). The structure elucidation of the new compound was achieved by HRFABMS and NMR spectroscopic analysis. The isolated compounds exhibited potent anti-austerity activity against four different human pancreatic cancer cell lines under nutrient-deprived conditions. The new compound 4′-O-methylgrynullarin (1) was also found to inhibit PANC-1 cell migration and colony formation under nutrient-rich condition. Mechanistically, compound 1 inhibited key survival proteins in the Akt/mTOR signaling pathway. Therefore, 4′-O-methylgrynullarin (1) can be considered as a potential lead compound for the anticancer drug development based on the anti-austerity strategy. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103279662&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/75656 |
ISSN: | 14643405 0960894X |
Appears in Collections: | CMUL: Journal Articles |
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