Please use this identifier to cite or link to this item:
http://cmuir.cmu.ac.th/jspui/handle/6653943832/75641
Title: | Blood-brain Barrier Dysfunction in Ischemic Stroke and Diabetes: the Underlying Link, Mechanisms and Future Possible Therapeutic Targets |
Authors: | Piyawadee Wicha Srijit Das Pasuk Mahakkanukrauh |
Authors: | Piyawadee Wicha Srijit Das Pasuk Mahakkanukrauh |
Keywords: | Biochemistry, Genetics and Molecular Biology;Medicine;Neuroscience |
Issue Date: | 1-Jun-2021 |
Abstract: | Ischemic stroke caused by occlusion of cerebral artery is responsible for the majority of stroke that increases the morbidity and mortality worldwide. Diabetes mellitus (DM) is a crucial risk factor for ischemic stroke. Prolonged DM causes various microvascular and macrovascular changes, and blood-brain barrier (BBB) permeability that facilitates inflammatory response following stroke. In the acute phase following stroke, BBB disruption has been considered the initial step that induces neurological deficit and functional disabilities. Stroke outcomes are significantly worse among DM. In this article, we review stroke with diabetes-induce BBB damage, as well as underlying mechanism and possible therapeutic targets for stroke with diabetes. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85109129916&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/75641 |
ISSN: | 20933673 20933665 |
Appears in Collections: | CMUL: Journal Articles |
Files in This Item:
There are no files associated with this item.
Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.