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dc.contributor.authorSutpirat Moonmuangen_US
dc.contributor.authorParunya Chaiyawaten_US
dc.contributor.authorSalinee Jantrapiromen_US
dc.contributor.authorDumnoensun Pruksakornen_US
dc.contributor.authorLuca Lo Piccoloen_US
dc.description.abstractCirculating cell-free nucleic acids recently became attractive targets to develop non-invasive diagnostic tools for cancer detection. Along with DNA and mRNAs, transcripts lacking coding potential (non-coding RNAs, ncRNAs) directly involved in the process of tumor pathogenesis have been recently detected in liquid biopsies. Interestingly, circulating ncRNAs exhibit specific expression patterns associated with cancer and suggest their role as novel biomarkers. However, the potential of circulating long ncRNAs (c-lncRNAs) to be markers in osteosarcoma (OS) is still elusive. In this study we performed a systematic review to identify thirteen c-lncRNAs whose altered expression in blood associate with OS. We herein discuss the potential impact that these c-lncRNAs may have on clinical decision-making in the management of OS. Overall, we aimed to provide novel insights that can contribute to the development of future precision medicine in oncology.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleCirculating long non-coding rnas as novel potential biomarkers for osteogenic sarcomaen_US
article.volume13en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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