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dc.contributor.authorThanawat Pattananandechaen_US
dc.contributor.authorSutasinee Apichaien_US
dc.contributor.authorSasithorn Sirilunen_US
dc.contributor.authorJakaphun Julsrigivalen_US
dc.contributor.authorKasirawat Sawangraten_US
dc.contributor.authorFumihiko Ogataen_US
dc.contributor.authorNaohito Kawasakien_US
dc.contributor.authorBusaban Sirithunyalugen_US
dc.contributor.authorChalermpong Saenjumen_US
dc.description.abstractFive glutinous purple rice cultivars and non-glutinous purple rice cultivated in different altitudes in the north of Thailand were collected. The samples were extracted using ethanol and determined for anthocyanins using HPLC. The total phenolic content (TPC), total flavonoid content (TFC), and the antioxidant, anti-inflammatory, and antimicrobial activities against foodborne pathogens were investigated. The highland glutinous cultivar named Khao’ Gam Luem-Phua (KGLP) extract had significantly high levels of cyanidin 3-O-glucoside, peonidin 3-O-glucoside, delphinidin 3-O-glucoside, TPC, and TFC, as well as exerting a potent antioxidant activity through ABTS assay (524.26 ± 4.63 VCEAC, mg L-ascorbic/g extract), lipid peroxidation (IC50 = 19.70 ± 0.31 µg/mL), superoxide anions (IC50 = 11.20 ± 0.25 µg/mL), nitric oxide (IC50 = 17.12 ± 0.56 µg/mL), a suppression effect on nitric oxide (IC50 = 18.32 ± 0.82 µg/mL), and an inducible nitric oxide synthase production (IC50 = 23.43 ± 1.21 µg/mL) in combined lipopolysaccharide-interferon-γ-activated RAW 264.7 murine macrophage cells. Additionally, KGLP also exhibited antimicrobial activity against foodborne pathogens, Staphylococcus aureus, Escherichia coli, Salmonella Enteritidis, and Vibrio parahaemolyticus. These results indicate that Thai glutinous purple rice cultivated on the highland could be a potent natural source of antioxidants, anti-inflammatories, and antimicrobial agents for use as a natural active pharmaceutical ingredient in functional food and nutraceutical products.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleAnthocyanin profile, antioxidant, anti-inflammatory, and antimicrobial against foodborne pathogens activities of purple rice cultivars in northern Thailanden_US
article.volume26en_US Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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