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dc.contributor.authorNutda Sutthammikornen_US
dc.contributor.authorVolaluck Supajaturaen_US
dc.contributor.authorHainan Yueen_US
dc.contributor.authorMiho Takahashien_US
dc.contributor.authorSunee Chansakaowen_US
dc.contributor.authorNobuhiro Nakanoen_US
dc.contributor.authorPu Songen_US
dc.contributor.authorTakasuke Ogawaen_US
dc.contributor.authorShigaku Ikedaen_US
dc.contributor.authorKo Okumuraen_US
dc.contributor.authorHideoki Ogawaen_US
dc.contributor.authorFrançois Niyonsabaen_US
dc.date.accessioned2022-10-16T06:57:38Z-
dc.date.available2022-10-16T06:57:38Z-
dc.date.issued2021-06-01en_US
dc.identifier.issn22237747en_US
dc.identifier.other2-s2.0-85106926313en_US
dc.identifier.other10.3390/plants10061122en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85106926313&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/75234-
dc.description.abstractNonhealing wounds are major socioeconomic challenges to healthcare systems worldwide. Therefore, there is a substantially unmet need to develop new drugs for wound healing. Gynura procumbens, a herb found in Southeast Asia, may be an effective therapeutic for nonhealing diabetic wounds. The aim of this study was to evaluate the efficacy of G. procumbens on wound healing in the diabetic milieu. G. procumbens extract was obtained using 95% ethanol and its components were determined by thin layer chromatography. Diabetes was induced in mice using streptozotocin. We found that G. procumbens extract contained stigmasterol, kaempferol and quercetin compounds. Topical application of G. procumbens on the wounded skin of diabetic mice accelerated wound healing and induced the expression of angiogenin, epidermal growth factor, fibroblast growth factor, trans-forming growth factor and vascular endothelial growth factor. Furthermore, G. procumbens promoted in vitro wound healing and enhanced the migration and/or proliferation of human endothelial cells, fibroblasts, keratinocytes and mast cells cultured in diabetic conditions. Finally, G. procumbens promoted vascular formation in the diabetic mice. To the best of our knowledge, this is the first study that evaluates in vivo wound healing activities of G. procumbens and activation of cells involved in wound healing process in diabetic conditions. The findings that G. procumbens accelerates wound healing and activates cells involved in the wound healing process suggest that G. procumbens might be an effective alternative therapeutic option for nonhealing diabetic wounds.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectEnvironmental Scienceen_US
dc.titleTopical gynura procumbens as a novel therapeutic improves wound healing in diabetic miceen_US
dc.typeJournalen_US
article.title.sourcetitlePlantsen_US
article.volume10en_US
article.stream.affiliationsJuntendo University Graduate School of Medicineen_US
article.stream.affiliationsXijing Hospitalen_US
article.stream.affiliationsJuntendo Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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