A Pilot Study of whether or Not Vegetable and Fruit Juice Containing Lactobacillus paracasei Lowers Blood Lipid Levels and Oxidative Stress Markers in Thai Patients with Dyslipidemia: A Randomized Controlled Clinical Trial

Abstract

Dyslipidemia is one of the risk factors of cardiovascular disease, which is the main cause of mortality worldwide. Meanwhile, lipid-lowering drug side-effects may also occur. Thus, consumption of vegetables and fruits containing probiotics is a good alternative to influence the lipid profile in plasma. This study investigated the effect of consuming vegetable and fruit juice (VFJ) with (probiotic group) and without probiotic Lactobacillus paracasei (placebo group), on the body weight, body mass index, waist circumference, lipid profile, lipid peroxidation, oxidative stress enzymes, and bile acid level in dyslipidemic patients (n = 20) at Bhumibol Adulyadej Hospital for 30 days. The levels of total cholesterol, low-density lipoprotein cholesterol, triglyceride (TG), and TG/high-density lipoprotein cholesterol (HDL-C) ratio in the probiotic group were significantly lower than those in the placebo group. The HDL-C concentration in the probiotic group was higher than that in the placebo group. The probiotic group showed significantly decreased malondialdehyde levels; increased oxidative stress enzymes, catalase and glutathione peroxidase in the plasma; and increased bile acid (BA) levels in the feces. Therefore, the findings of this study demonstrate that VFJ enriched with probiotic L. paracasei may represent an alternative method for the prevention of dyslipidemia during the primary intervention stage for patients who are not yet taking other medication.