Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/74640
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dc.contributor.authorChaiyavat Chaiyasuten_US
dc.contributor.authorBhagavathi Sundaram Sivamaruthien_US
dc.contributor.authorPatchareepon Jungsinyatamen_US
dc.contributor.authorChawin Tansrisooken_US
dc.contributor.authorDamrongsak Jinaraten_US
dc.contributor.authorKhontaros Chaiyasuten_US
dc.contributor.authorSartjin Peerajanen_US
dc.contributor.authorWandee Rungseevijitprapaen_US
dc.date.accessioned2022-10-16T06:45:39Z-
dc.date.available2022-10-16T06:45:39Z-
dc.date.issued2022-08-01en_US
dc.identifier.issn20763417en_US
dc.identifier.other2-s2.0-85137342279en_US
dc.identifier.other10.3390/app12168324en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137342279&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/74640-
dc.description.abstractFeatured Application: The study describes the optimum conditions to produce a sea buckthorn oil-loaded nanostructured lipid carrier (SBO-NLC) for improved skin hydration. The results suggested that the SBO-NLC could be a potent agent for preventing skin dehydration. Sea buckthorn (SB) (Elaeagnus rhamnoides (L.) A. Nelson) is rich in flavonoids, phenolic compounds, anthocyanins, carotenoids, and phytosterol. Its phytochemicals exhibit various biological activities, such as antioxidant, immunomodulatory and anti-carcinogenic activities. SB also helps prevent the development of wrinkles and protects the skin’s surface from UV rays. The purpose of the present study was to develop and characterize an SB oil (SBO)-loaded nanostructured lipid carrier (NLC) for improved skin hydration. The response surface methodology (RSM) and central composite design (CCD) were employed to optimize the influencing factors (wax percentage, surfactant percentage, and PEG400 percentage in the surfactant) to achieve the desirable qualities in SBO-NLCs. The optimum (minimum) size of SBO-NLCs (105.26 nm) was obtained with a combination of 2.5% wax, 7.5% surfactant, and 30% PEG400 in the surfactant. A narrow polydispersity index (PDI; 0.16), relatively low zeta potential (ZP; −15.63 mV), and high entrapment efficiency (EE; 90.88%) were observed in this study. Reduced quadratic and reduced 2FI models were adapted to predict conditions to attain the optimum size and PDI of SBO-NLCs, respectively. ZP and EE were predicted with the help of a reduced cubic model. All of the predicted models were statistically significant. Differential scanning calorimetry results suggested that the SBO-NLCs had less crystallinity and therefore reduced the rate of drug expulsion from the inner core of the NLCs. A noticeable level of occlusion effect was observed in the SBO-NLCs. The SBO-NLCs showed a faster vitamin E (biomarker for the drug) release rate into the skin within 24 h, and the released vitamin E level after 48 h was significantly higher than that for the free SBO. Additionally, SBO-NLCs delivered vitamin E into the inner skin significantly (22.73 ± 1.67 µg/cm2 of skin). In conclusion, the SBO-NLC is a potential delivery system that can be used to prevent skin water loss and improve skin hydration. Further investigations, such as drug stability and safety evaluations, are required prior to commercialization for human use.en_US
dc.subjectChemical Engineeringen_US
dc.subjectComputer Scienceen_US
dc.subjectEngineeringen_US
dc.subjectMaterials Scienceen_US
dc.titleDevelopment and Evaluation of Elaeagnus rhamnoides (L.) A. Nelson Oil-Loaded Nanostructured Lipid Carrier for Improved Skin Hydrationen_US
dc.typeJournalen_US
article.title.sourcetitleApplied Sciences (Switzerland)en_US
article.volume12en_US
article.stream.affiliationsChiang Mai Rajabhat Universityen_US
article.stream.affiliationsUbon Ratchathani Universityen_US
article.stream.affiliationsMae Fah Luang Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsHealth Innovation Instituteen_US
Appears in Collections:CMUL: Journal Articles

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