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dc.contributor.authorMati Chuamanochanen_US
dc.contributor.authorSutthinee Phuprasertsaken_US
dc.contributor.authorPuncharas Weesasubpongen_US
dc.contributor.authorChidchanok Ruengornen_US
dc.contributor.authorChabaphai Phosuyaen_US
dc.contributor.authorRatanaporn Awiphanen_US
dc.contributor.authorBrian Huttonen_US
dc.contributor.authorKednapa Thavornen_US
dc.contributor.authorJonathan A. Bernsteinen_US
dc.contributor.authorSurapon Nochaiwongen_US
dc.description.abstractBackground: Hereditary angioedema (HAE) is a rare genetic disease that can lead to potentially life-threatening airway attacks. Although novel therapies for HAE treatment have become available over the past decades, a comparison of all available treatments has not yet been conducted. As such, we will perform a systematic review and network meta-analysis to identify the best evidence-based treatments for the management of acute attacks and prophylaxis of HAE. Methods: This study will include both parallel and crossover randomized controlled trials that have investigated prevention or treatment strategies for HAE attacks. We will search electronic databases, including Medline, Embase, PubMed, Cochrane Library, Scopus, and CINAHL, from inception with no language restrictions. Potential trials will be supplemented through a gray literature search. The process of study screening, selection, data extraction, risk-of-bias assessment, certainty assessment and classification of treatments will be performed independently by a pair of reviewers. Any discrepancy will be addressed through team discussion. A two-step approach of pairwise and network meta-analysis will be performed. The summarized effect estimates of direct and indirect treatment comparisons will be pooled using DerSimonion–Laird random-effects models. The incoherence assumption, in terms of the consistency of direct and indirect effects, will be assessed. An evidence-based synthesis will be performed, based on the magnitudes of effect size, evidence certainty, and ranking of treatment effects, with respect to treatment benefits and harms. Discussion: This systematic review and network meta-analysis will summarize evidence-based conclusions with respect to the ratio of benefits and harms arising from interventions for the treatment of acute attacks and prophylaxis of HAE. Evidence from this network estimate could promote the rational use of interventions among people living with HAE in clinical practice settings. PROSPERO registration number: CRD42021251367.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleBenefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trialsen_US
article.volume13en_US of Medicine, Chiang Mai Universityen_US of Ottawaen_US of Cincinnati College of Medicineen_US Nakorn Chiang Mai Hospitalen_USé d'Ottawa, Faculté de Médecineen_US Hospital Research Instituteen_US Mai Universityen_US
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