Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/74360
Title: Phytochemical Constitution, Anti‐Inflammation, Anti‐Androgen, and Hair Growth‐Promoting Potential of Shallot (Allium ascalonicum L.) Extract
Authors: Warintorn Ruksiriwanich
Chiranan Khantham
Anurak Muangsanguan
Chuda Chittasupho
Pornchai Rachtanapun
Kittisak Jantanasakulwong
Yuthana Phimolsiripol
Sarana Rose Sommano
Korawan Sringarm
Emilia Ferrer
Francisco J. Barba
Authors: Warintorn Ruksiriwanich
Chiranan Khantham
Anurak Muangsanguan
Chuda Chittasupho
Pornchai Rachtanapun
Kittisak Jantanasakulwong
Yuthana Phimolsiripol
Sarana Rose Sommano
Korawan Sringarm
Emilia Ferrer
Francisco J. Barba
Keywords: Agricultural and Biological Sciences;Environmental Science
Issue Date: 1-Jun-2022
Abstract: In Thai folklore wisdom, shallot (Allium ascalonicum L.) was applied as a traditional herbal medicine for hair growth promotion with no scientific evidence. Androgenetic alopecia (AGA) is a progressive hair loss caused by multiple factors, including androgen hormones, inflammation, and oxidative stress. Conventional medicines (finasteride, dutasteride, corticosteroids, and minoxidil) have been used with limited therapeutic efficacy and unpleasant side effects. In this study, we aimed to give the first estimation of bioactive compounds in shallot extract and evaluate the hair growth‐promoting activities regarding anti‐inflammatory and gene expression modulation involving androgen, Wnt/β‐catenin, sonic hedgehog, and angiogenesis pathways. The results reveal that phenolic compounds (quercetin, rosmarinic, and p‐coumaric acids) are the major constituents of the methanolic shallot extract. Compared with the lipopolysaccharide‐stimulated control group (2.68 ± 0.13 μM), nitric oxide production was remarkably diminished by shallot extract (0.55 ± 0.06 μM). Shallot extract improves hair growth promotion activity, as reflected by the downregulation of the androgen gene expression (SRD5A1 and SRD5A2) and the upregulation of the genes associated with Wnt/β‐catenin (CTNNB1), sonic hedgehog (SHH, SMO, and GIL1), and angiogenesis (VEGF) pathways. These findings disclose the new insights of shallot extract on hair growth promotions. Shallot extract could be further developed as nutraceutical, nutricosmetic, and cosmeceutical preparations for AGA treatment.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131158008&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/74360
ISSN: 22237747
Appears in Collections:CMUL: Journal Articles

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