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DC Field | Value | Language |
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dc.contributor.author | Panwad Harn-a-morn | en_US |
dc.contributor.author | Chanane Wanapirak | en_US |
dc.contributor.author | Supatra Sirichotiyakul | en_US |
dc.contributor.author | Kasemsri Srisupundit | en_US |
dc.contributor.author | Fuanglada Tongprasert | en_US |
dc.contributor.author | Suchaya Luewan | en_US |
dc.contributor.author | Theera Tongsong | en_US |
dc.date.accessioned | 2022-05-27T08:37:13Z | - |
dc.date.available | 2022-05-27T08:37:13Z | - |
dc.date.issued | 2022-01-01 | en_US |
dc.identifier.issn | 18793479 | en_US |
dc.identifier.issn | 00207292 | en_US |
dc.identifier.other | 2-s2.0-85125241757 | en_US |
dc.identifier.other | 10.1002/ijgo.14140 | en_US |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85125241757&origin=inward | en_US |
dc.identifier.uri | http://cmuir.cmu.ac.th/jspui/handle/6653943832/73225 | - |
dc.description.abstract | Objective: To evaluate the effectiveness of ultrasound algorithm in diagnosis of fetal Hb Bart’s disease among pregnancies at risk. Methods: Pregnancies at risk underwent ultrasound for the first time at 12–14 weeks of gestation and serial ultrasound every 2–4 weeks until 24 weeks to identify pre-hydropic signs. The invasive procedure was omitted in case of no pre-hydropic signs. Results: A total of 237 fetuses were recruited, including 53 affected and 184 unaffected fetuses. The algorithm has a sensitivity of 100% in the detection of fetal Hb Bart’s disease with a false positive rate of 10.9%. Of the affected group, the mean gestational age at the time of diagnosis was 15.5 ± 2.6 week. 30.8% of all pregnancies at risk underwent invasive procedures. The algorithm had a 70% reduction in the rate of invasive procedures among pregnancies at risk without missing the affected cases. Conclusions: The algorithm is highly effective in the early detection of fetal Hb Bart’s disease with a detection rate of 100%, and invasive diagnosis can be avoided in about 70% of cases. Thus, this algorithm should be used as a guideline for prenatal diagnosis of fetal Hb Bart’s disease, especially in geographical areas of high prevalence. | en_US |
dc.subject | Medicine | en_US |
dc.title | Effectiveness of ultrasound algorithm in prenatal diagnosis of hemoglobin Bart’s disease among pregnancies at risk | en_US |
dc.type | Journal | en_US |
article.title.sourcetitle | International Journal of Gynecology and Obstetrics | en_US |
article.stream.affiliations | Chiang Mai University | en_US |
Appears in Collections: | CMUL: Journal Articles |
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