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dc.contributor.authorThida Kaewkoden_US
dc.contributor.authorPiyada Wangroongsarben_US
dc.contributor.authorItthayakorn Promputthaen_US
dc.contributor.authorYingmanee Tragoolpuaen_US
dc.identifier.citationChiang Mai Journal of Science 48, 1 (January 2021), 56-73en_US
dc.descriptionThe Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science are welcomed except in areas such as agriculture, engineering and medical science which are outside the scope of the Journal. Currently, we focus on manuscripts in biology, chemistry, physics, materials science and environmental science. Papers in mathematics statistics and computer science are also included but should be of an applied nature rather than purely theoretical. Manuscripts describing experiments on humans or animals are required to provide proof that all experiments have been carried out according to the ethical regulations of the respective institutional and/or governmental authorities and this should be clearly stated in the manuscript itself. The Editor reserves the right to reject manuscripts that fail to do so.en_US
dc.description.abstractThe aqueous extracts of Camellia sinensis leaf including green tea, oolong tea and black tea, and sixteen medicinal plants were evaluated for their effects on growth of Helicobacter pylori. Phytochemical compounds; phenolic and tea catechins, were identified in different types of tea leaf extract. Green tea leaf extract revealed a high amount of tea catechins such as epigallocatechin gallate, epicatechins, caffeine and gallic acid. In addition, oolong tea contained high amounts of epigallocatechins and catechins. Moreover, all plant extracts demonstrated the phenolic compounds and several phytochemical groups; simple phenol, phenolic acids and flavonols. Green tea leaf extract showed the highest phenolic content at a value of 315.09, 10.16 mg GAE/g extract and the greatest antioxidant activity in inhibiting DPPH radicals by 170.51, 3.68 mg GAE/g extract. Extracts of tea leaves and medicinal plants especially Aegle marmelos and Terminalia catappa could inhibit the standard strain, H. pylori DMST20165 and two isolates of H. pylori; No. 31 and 36. The greatest anti-H. pylori activity was observed in the green tea extract at a minimal inhibitory concentration (MIC) and a minimal bactericidal concentration (MBC) of 3.91 mg/mL. Tea leaf extract and the extracts of A. marmelos and T. catappa were also able to inhibit urease enzyme production and the adhesion of all tested H. pylori on epithelial cells. Therefore, tea leaf extracts and plant extracts of A. marmelos, and T. catappa could be considered as antioxidants and potential agents for the treatment of H. pylori infection.en_US
dc.publisherFaculty of Science, Chiang Mai Universityen_US
dc.subjectcell adhesionen_US
dc.subjectH. pylorien_US
dc.subjectmedicinal planten_US
dc.subjectphytochemical compounden_US
dc.subjecttea leafen_US
dc.titleInhibitory Efficacy of Camellia sinensis Leaf and Medicinal Plant Extracts on Helicobacter pylori Standard and Isolate Strains Growth, Urease Enzyme Production and Epithelial Cell Adhesionen_US
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