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dc.contributor.authorMaria Latifen_US
dc.contributor.authorMehwish Faheemen_US
dc.contributor.authorSeyed Hossein Hoseinifaren_US
dc.contributor.authorHien Van Doanen_US
dc.description.abstract© 2020 Elsevier B.V. The current study assessed the ameliorative potential of Nigella sativa seeds against diethyl phthalate (DEP) induced growth retardation, oxidative stress and histo-biochemical changes in Labeo rohita (rohu) fingerlings. N. sativa, a medicinal plant containing several pharmacological properties, was incorporated into three diets at 0%, 1%, and 2.5% levels, prepared by mixing N. sativa seeds with the basal diet. The median lethal concentration of DEP to rohu was 4.38 mg L−1 for 96th hour. Three hundred fingerlings (8.502 ± 0.009 g) were exposed to a sub-lethal concentration of 0.51 mg L−1 (1/10th of LC50) DEP, with or without N. sativa for 7, 14, 21, and 28 days. The results revealed that rohu exposed to DEP alone has significantly decreased growth rate, as opposed to rohu exposed to DEP in combination with N. sativa, which demonstrated markedly improved growth rates. A significant decrease in muscles protein contents of DEP-treated rohu was also noted. DEP exposure also inhibited the antioxidant enzymes (catalase, glutathione-S-transferase and glutathione peroxidase) activities in all of the studied tissues (liver, kidney, gills and brain). Moreover, DEP exposure significantly increased lipid peroxidation levels, whereas glutathione (GSH) levels decreased in all of the studied rohu tissues in a time-dependent manner. Where DEP exposure has been found to enhance alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, urea, and creatinine levels; a significant reversal in the levels of these enzymes was noted in N. sativa supplemented rohu. Histological studies of the liver, kidney, and gills indicated that N. sativa supplementation in rohu provides beneficial protective defenses against DEP-induced toxicity.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.titleProtective efficacy of Nigella sativa seeds against diethyl phthalate induced growth retardation, oxidative stress and histo-biochemical damages in Labeo rohitaen_US
article.volume533en_US of the Punjab, Lahoreen_US College University Lahoreen_US University of Agricultural Sciences and Natural Resourcesen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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