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dc.contributor.authorSarayut Lahnwongen_US
dc.contributor.authorSiripong Paleeen_US
dc.contributor.authorNattayaporn Apaijaien_US
dc.contributor.authorSirawit Sriwichaiinen_US
dc.contributor.authorSasiwan Kerdphooen_US
dc.contributor.authorThidarat Jaiwongkamen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.contributor.authorNipon Chattipakornen_US
dc.description.abstract© 2020 The Author(s). Background: A sodium-glucose co-transporter 2 (SGLT-2) inhibitor had favorable impact on the attenuation of hyperglycemia together with the severity of heart failure. However, the effects of acute dapagliflozin administration at the time of cardiac ischemia/reperfusion (I/R) injury are not established. Methods: The effects of dapagliflozin on cardiac function were investigated by treating cardiac I/R injury at different time points. Cardiac I/R was instigated in forty-eight Wistar rats. These rats were then split into 4 interventional groups: control, dapagliflozin (SGLT2 inhibitor, 1 mg/kg) given pre-ischemia, at the time of ischemia and at the beginning of reperfusion. Left ventricular (LV) function and arrhythmia score were evaluated. The hearts were used to evaluate size of myocardial infarction, cardiomyocyte apoptosis, cardiac mitochondrial dynamics and function. Results: Dapagliflozin given pre-ischemia conferred the maximum level of cardioprotection quantified through the decrease in arrhythmia, attenuated infarct size, decreased cardiac apoptosis and improved cardiac mitochondrial function, biogenesis and dynamics, leading to LV function improvement during cardiac I/R injury. Dapagliflozin given during ischemia also showed cardioprotection, but at a lower level of efficacy. Conclusions: Acute dapagliflozin administration during cardiac I/R injury exerted cardioprotective effects by attenuating cardiac infarct size, increasing LV function and reducing arrhythmias. These benefits indicate its potential clinical usefulness.en_US
dc.titleAcute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injuryen_US
article.title.sourcetitleCardiovascular Diabetologyen_US
article.volume19en_US Kaen Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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