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dc.contributor.authorPiranit Nik Kantaputraen_US
dc.contributor.authorKanich Tripuwabhruten_US
dc.contributor.authorWorrachet Intachaien_US
dc.contributor.authorBruce M. Carlsonen_US
dc.contributor.authorNatalina Quartoen_US
dc.contributor.authorChumpol Ngamphiwen_US
dc.contributor.authorSissades Tongsimaen_US
dc.contributor.authorNuntigar Sonsuwanen_US
dc.description.abstract© 2020 John Wiley & Sons Ltd Treacher Collins syndrome (TCS: OMIM 154500) is an autosomal dominant craniofacial disorder belonging to the heterogeneous group of mandibulofacial dysostoses. Objective: To investigate four Treacher Collins syndrome patients of the Sgaw Karen family living in Thailand. Method: Clinical examination, hearing tests, lateral cephalometric analyses, Computed tomography, whole exome sequencing and Sanger direct sequencing were performed. Results: All of the patients affected with Treacher Collins syndrome carried a novel TCOF1 mutation (c.4138_4142del; p.Lys1380GlufsTer12), but clinically they did not have the typical facial gestalt of Treacher Collins syndrome, which includes downward-slanting palpebral fissures, colobomas of the lower eyelids, absence of eyelashes medial to the colobomas, malformed pinnae, hypoplastic zygomatic bones and mandibular hypoplasia. Lateral cephalometric analyses identified short anterior and posterior cranial bases, and hypoplastic maxilla and mandible. Computed tomography showed fusion of malleus and incus, sclerotic mastoid, hypoplastic middle ear space with a soft tissue remnant, dehiscence of facial nerve and monopodial stapes. Conclusion: Treacher Collins syndrome in Sgaw Karen patients has not been previously documented. This is the first report of monopodial stapes in a TCS patient who had a TCOF1 mutation. The absence of a common facial phenotype and/or the presence of monopodial stapes may be the effects of this novel TCOF1 mutation.en_US
dc.titleTreacher Collins syndrome: A novel TCOF1 mutation and monopodial stapesen_US
article.title.sourcetitleClinical Otolaryngologyen_US
article.volume45en_US University School of Medicineen_US of Michigan, Ann Arboren_US National Center for Genetic Engineering and Biotechnologyen_US Mai Universityen_US Clinicen_US
Appears in Collections:CMUL: Journal Articles

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