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Title: Antioxidant and moisturizing properties of carboxymethyl chitosan with different molecular weights
Authors: Nareekan Chaiwong
Pimporn Leelapornpisid
Kittisak Jantanasakulwong
Pornchai Rachtanapun
Phisit Seesuriyachan
Vinyoo Sakdatorn
Noppol Leksawasdi
Yuthana Phimolsiripol
Keywords: Chemistry
Materials Science
Issue Date: 1-Jul-2020
Abstract: © 2020 by the authors. This research aimed to synthesize carboxymethyl chitosan (CMCH) from different molecular weights of chitosan including low MW (L, 50-190 kDa), medium MW (M, 210-300 kDa) and high MW (H, 310-375 kDa) on the antioxidant and moisturizing properties. The L-CMCH, M-CMCH and H-CMCH improved the water solubility by about 96%, 90% and 89%, respectively when compared to native chitosan. Higher MW resulted in more viscous of CMCH. For antioxidant properties, IC50 values of DPPH and ABTS radical scavenging activity for L-CMCH were 1.70 and 1.37 mg/mL, respectively. The L-CMCH had higher antioxidant properties by DPPH and ABTS radical scavenging assay and FRAP. The moisturizing properties on pig skin using a Corneometer® showed that 0.5% H-CMCH significantly presented (p ≤ 0.05) greater moisturizing effect than that of untreated-skin, distilled water, propylene glycol and pure chitosan from three molecular weights.
ISSN: 20734360
Appears in Collections:CMUL: Journal Articles

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