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dc.contributor.authorChuthamat Duangkamolen_US
dc.contributor.authorWong Phakhodeeen_US
dc.contributor.authorMookda Pattarawarapanen_US
dc.description.abstract© 2020 Georg Thieme Verlag. All rights reserved. A convenient oxidative cyclodesulfurization method toward the synthesis of benzofused nitrogen heterocycles using inexpensive and readily available potassium periodate as an oxidant was developed. Upon treating isothiocyanates with ortho -substituted anilines bearing N, N -, N, O -, and N, S -bis-nucleophiles, followed by an intramolecular cyclization of the in situ generated monothioureas, substituted 2-aminobenzazole series were rapidly accessible in good to excellent yields. The protocol can accommodate various substituents on both substrates while allowing more efficient, greener, and operational simpler process relative to other oxidative coupling reactions. Tetracyclic quinazolinone derivatives were also afforded in high yields in a single preparative step and chromatography-free.en_US
dc.subjectChemical Engineeringen_US
dc.titlePotassium Periodate Mediated Oxidative Cyclodesulfurization toward Benzofused Nitrogen Heterocyclesen_US
article.title.sourcetitleSynthesis (Germany)en_US
article.volume52en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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