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dc.contributor.authorPachabadee Marsupen_US
dc.contributor.authorKankanit Yeerongen_US
dc.contributor.authorWaranya Neimkhumen_US
dc.contributor.authorJakkapan Sirithunyalugen_US
dc.contributor.authorSongyot Anuchapreedaen_US
dc.contributor.authorChaiwat To-Anunen_US
dc.contributor.authorWantida Chaiyanaen_US
dc.description.abstract© 2020 by the authors. This study aimed to develop nanoemulsions for enhancing chemical stability and dermal delivery of Cordyceps militaris extracts. C. militaris was extracted by maceration and infusion. The extracts were investigated for cordycepin, phenolic, and flavonoid content. The antioxidant activity was investigated by in vitro spectrophotometric methods. The irritation profile was investigated by hen’s egg-chorioallantoic membrane test. Nanoemulsions were developed using high-pressure homogenizer. C. militaris extract was incorporated into the nanoemulsion and investigated for safety, release profile, permeation, and skin retention. The results demonstrated that water extract (CW) contained the significantly highest content of cordycepin, phenolics, and flavonoids, which were responsible for antioxidant activity. CW was the most potent antioxidant. CW possessed comparable 2,2′-diphenyl-1-picrylhydrazyl radical scavenging activity and lipid peroxidation inhibition to l-ascorbic acid (96.9 ± 3.1%) and alpha-tocopherol (87.2 ± 1.0%). Consequently, ten mg/mL of CW was incorporated into nanoemulsions composing of sugar squalene, Tween® 85, and deionized water. Nanoemulsion, which had the smallest internal droplet size (157.1 ± 2.6 nm), enhanced the stability of CW, had no cytotoxicity effect and no skin irritation, released the most CW (0.9 ± 0.0% w/w after 24 h), and delivered the highest CW into the skin layer (33.5 ± 0.7% w/w). Therefore, nanoemulsion was suggested for enhancing the stability and dermal delivery of CW.en_US
dc.subjectChemical Engineeringen_US
dc.subjectMaterials Scienceen_US
dc.titleEnhancement of chemical stability and dermal delivery of cordyceps militaris extracts by nanoemulsionen_US
article.volume10en_US Chalermprakiet Universityen_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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