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Title: HIV RNA measurement in dried blood spots of HIV-infected patients in Thailand using Abbott m2000 system
Authors: Woottichai Khamduang
Ampika Kaewbundit
Amonrat Duangmano
Sayamon Hongjaisee
Virat Klinbuayaem
Guttiga Halue
Apichat Chutanunta
Wasna Sirirungsi
Gonzague Jourdain
Nicole Ngo-Giang-Huong
Keywords: Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2020
Abstract: © 2020 Khamduang et al. World Health Organization recommends using dried blood spots (DBS) for HIV RNA viral load (VL) measurement whenever plasma processing is not convenient or feasible. DBS collected from 80 treatment-naïve HIV-infected patients presenting in three hospitals of two different regions of Thailand were shipped to a central laboratory along with corresponding plasma specimens. Viral load was measured in both DBS and plasma using the Abbott m2000 system. HIV RNA levels were strongly correlated (r = 0.94) with a mean of differences of 0.23 log10 copies/mL. Using the 1,000 copies/mL cut-off, the sensitivity of DBS was 97% (95%CI, 91-100%) and specificity was 75% (95%CI, 19-99%). DBS are useful to scale-up HIV RNA VL testing in settings with limited access to VL testing.
ISSN: 19326203
Appears in Collections:CMUL: Journal Articles

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