Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/67569
Title: (R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities
Authors: Thanika Promchai
Thanaphat Thaima
Roonglawan Rattanajak
Sumalee Kamchonwongpaisan
Stephen G. Pyne
Thunwadee Limtharakul
Keywords: Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Chemistry
Issue Date: 1-Jan-2019
Abstract: © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. A new farnesylindole, (R)-3-(8'-hydroxyfarnesyl)-indole (1), as a scalemic mixture (33% ee) along with nine known compounds (2-10), including one farnesylindole, three flavanones, three flavone derivatives and two chalcone derivatives were isolated from the methanolic crude extract of the flowers from Anomianthus dulcis. All compounds were purified by appropriate chromatographic techniques and their structures elucidated by spectroscopic methods. Compounds 1, 2 and 8 showed moderate antiplasmodial activities against TM4/8.Two and K1CB1 strains of which compound 2 displayed the best activity with IC50 values of 27.9 ± 2.57 and 21.4 ± 1.68 µM, respectively. In addition, compound 1 also presented modest cytotoxicity against a KB cell line with an IC50 value of 22.3 ± 0.39 µM. None of these compounds showed cytotoxicity against Vero cells.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076485476&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/67569
ISSN: 14786427
14786419
Appears in Collections:CMUL: Journal Articles

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