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Title: Quantitative stress radionuclide myocardial perfusion imaging can indicate significant coronary artery stenosis
Authors: Tarit Taerakul
Araya Boonyaleepan
Siriwan Sisai
Thewarug Werawatganon
Keywords: coronary artery disease
radionuclide myocardial perfusion imaging
quantitative analysis
Issue Date: 2019
Publisher: Faculty of Medicine
Citation: Chiang Mai Medical Journal 58,3 (July-September 2019), 123-132
Abstract: Objective The objective of this study was to evaluate the effectiveness of quantitative assessment of radionuclide myocardial perfusion imaging in indicating signifi cant coronary artery stenosis.MethodsSeven hundred and twenty patients with suspicion of coronary artery disease were retrospec-tively identifi ed. All had undergone cardiac catheterization within a 6-month period aft er having had a one-day pharmacologic stress radionuclide myocardial perfusion scan. Important parameters analyzed included myocardial perfusion, wall motion, wall thickening severity scores of 3 coronary artery terri-tories and left ventricular ejection fraction values. Th ese parameters were subsequently compared with currently the gold standard for cardiac catheterization. Results Binary logistic regression analysis found that patients who had signifi cant coronary artery ste-nosis had signifi cantly higher values in all quantitative parameters (mean severity scores in myocardial perfusion, wall motion, wall thickening in most of the 3 coronary artery territories) than those in the non-signifi cant group (p<0.05) with the exception of the wall motion severity score of the left circumfl ex artery. Similarly, patients with higher perfusion severity scores had a higher probability of signifi cant coronary artery stenosis in all three coronary arteries. ConclusionQuantitative parameters obtained from stress radionuclide myocardial perfusion imaging can indicate signifi cant coronary artery stenosis in all three main coronary arteries at a level comparable with that of cardiac catheterization which is currently the gold standard method but it is superior to cardiac catherization due to less invasive and less expensive. Higher perfusion severity scores indicate a higher probability of signifi cant coronary artery stenosis. Chiang Mai Medical Journal 2019;58(3):123-32.
Description: Chiang Mai Medical Journal (Formerly Chiang Mai Medical Bulletin) is an official journal of the Faculty of Medicine, Chiang Mai University. It accepts original papers on clinical and experimental research that are pertinent in the health sciences. The Journal is published 4 issues/year (i.e., Mar, Jun, Sep, and Dec). Original articles, review articles, brief reports, case reports, and miscellany (editorials, perspectives, opinions, and letters to the editor) are welcome. All manuscripts submitted to Chiang Mai Medical Journal must not have been previously published (except in abstract form) or under consideration for publication elsewhere. Each submitted article will be reviewed by two referrees or more. Following publication, Chiang Mai Medical Journal reserves the copyright of all published materials and such materials may not be reproduced in any form without written permission from Chiang Mai Medical Journal. We strongly recommend that authors follow the guideline in manuscript preparation below. Failure to comply with the instruction will result in delay the processing of your paper
ISSN: 0125-5983
Appears in Collections:CMUL: Journal Articles

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