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Title: Biological Activitiesof Integric Acid Isolated from the Wood-Decay Fungus Xylaria feejeensis 2FB-PPM08M
Authors: Totsaporn Srisapoomi"
Tsuyoshi Ichiyanagi
Hiromitsu Nakajima
Tadanori Aimi
Sophon Boonlue
Keywords: Biological activities
Integric acid
Wood-decay fungus
Xylaria feejeensis
Issue Date: 2015
Publisher: Science Faculty of Chiang Mai University
Citation: Chiang Mai Journal of Science 42, 1 (Jan 2015), 70 - 78
Abstract: Integric acid was isolated from the wood-decay fungus Xylaria feejeensis strain 2FB-PPM08M grown on potato dextrose broth. The compound showed weak antimicrobial activity against Gram-positive bacteria. However, it was inactive against M. tuberculosis and had no antiviral effects on HSV-1 and H5N1 viruses. Notably, the metabolite exhibited inhibitory activity against the malarial parasite Plasmodium falciparum K1 strain, with IC50 values of 6.91 µM, and non-cytotoxicity against African green monkey kidney fibroblasts (Vero cells). This is the first report on its activity against P. falciparum.
ISSN: 0125-2526
Appears in Collections:CMUL: Journal Articles

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