Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/66602
Title: Lipocalin-2: Its perspectives in brain pathology and possible roles in cognition
Authors: Kanokporn Pinyopornpanish
Nipon Chattipakorn
Siriporn C. Chattipakorn
Keywords: Biochemistry, Genetics and Molecular Biology
Medicine
Neuroscience
Issue Date: 1-Jan-2019
Abstract: © 2019 British Society for Neuroendocrinology Lipocalin-2 (LCN2) has been known to play an important role in pathological conditions, specifically in response to inflammation, infection and injury to cells. Recently, several research teams have been interested in investigating its association with cognition during the progression of pathology. Previous studies have demonstrated that LCN2 is not correlated with cognitive function under normal physiological conditions, although LCN2 has been negatively associated with cognition and some neuropathologies. Increasing LCN2 production is associated with reduced cognitive performance in a rodent model. However, further studies are needed to explore the potential underlying mechanisms of LCN2 on cognitive dysfunction, as well as its clinical relevance. This review aims to summarise the evidence available from in vitro, in vivo and clinical studies concerning the possible role of LCN2 on cognitive function following the onset of pathological conditions. Any contradictory evidence is also assessed and presented.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071315817&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/66602
ISSN: 13652826
09538194
Appears in Collections:CMUL: Journal Articles

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