Ferric-Tannic Nanoparticles Increase Neuronal Cellular Clearance

Abstract

Copyright © 2019 American Chemical Society. Targeting cellular clearance function in brain cells provides new opportunities for the prevention of dementia by clearance of potentially dangerous molecules. Herein, we present a new approach to enhancing neuroactive and neuroprotective activities in a neuronal cell line using ferric-tannic nanoparticles (FTs). Major biological functions mediated by FTs were clearly found to promote neuronal tube growth through the activation of axon guidance pathways. A number of neuronal tubes were found to increase under stimulation of amyloid beta-peptides, oxidative stress, and serum deprivation. The neuronal tubes generated play a role in clearing debris and amyloid beta-peptides. Another key function in cellular clearance mediated by FTs was their capability of inducing autophagy with the activation of lysosomes. Therefore, FTs are a promising new strategy for brain cell protection through the activation of the cellular clearance function. Hopefully, our findings will pave the way for the development of new methods for the prevention and therapy of dementia.